A Comparative Study Between The Therapeutic Role of Adipose Derived Mesenchymal Stem Cells and Omeprazole in Regeneration of Gastric Ulcer Induced by Aspirin in Albino Rats : Histological and Immunohistochemical Study | ||
| Egyptian Journal of Histology | ||
| Article 10, Volume 44, Issue 4, December 2021, Pages 993-1006 PDF (2.59 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejh.2020.28223.1277 | ||
| Authors | ||
| Hanan Ibrahim Elkerdasy* 1; Hend Ragab Mousa2 | ||
| 1anatomy department, faculty of medicine, benha university | ||
| 2anatomy department, faculty of medicine, benha univrsity | ||
| Abstract | ||
| Background: Aspirin induced gastric mucosal injury, which leads to gastric ulcer. Adipose Derived Mesenchymal Stem Cells (ADMSC) can be used for treatment of gastric ulcer as they can differentiate into many cell types. Omeprazole is used for treatment of gastric acid-related disorders. The Aim of the Work: Was to compare between the therapeutic role of ADSMC and omeprazole in treatment of gastric ulcer Material and Methods: Forty male albino rats were divided into four equal groups: 1-Control group. 2-Aspirin group in which rats were fasted for 24 hours, then given acetylsalicylic acid (200 mg/kg) once orally for induction of ulcer. 3-ADMSC-treated group in which rats were treated by (3 × 10⁶) ADMSCs/ rat once by intravenous injection four hours after induction of ulcer. 4-Omeprazole-treated group in which rats were treated by omeprazole suspension (20 mg/kg) orally, four hours after induction of ulcer, and for five days. Gastric juice volume and acidity, length of gastric ulcer, and histopathological and immunohistochemical changes of the stomach were all evaluated. Results: Aspirin induced erosion and loss of architecture of gastric mucosal epithelium, ADMSC treatment reduced the length of gastric ulcer, ameliorate histopathological changes and reduced the PCNA-LI also the omeprazole treatment promoted healing of the gastric ulcer induced by aspirin but the therapeutic role of ADMSC was significantly lower in ulcer index and PCNA-LI and better in PAS reaction and histopathological healing of gastric ulcer than the therapeutic role of omeprazole. Conclusion: The therapeutic role of ADMSC was found to be superior to omeprazole in treatment of gastric ulcer. | ||
| Keywords | ||
| ADMSC; aspirin; gastric ulcer; omeprazole | ||
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