ABOUEL-NOUR, M., EL-SHEWEHY, D., HAMADA, S., MORSY, T. (2015). THE EFFICACY OF THREE MEDICINAL PLANTS: GARLIC, GINGER AND MIRAZID AND A CHEMICAL DRUG METRONIDAZOLE AGAINST CRYPTOSPORIDIUM PARVUM. I- IMMUNOLOGICAL RESPONSE. test, 45(3), 559-570. doi: 10.21608/jesp.2015.96295
MOHAMED F. ABOUEL-NOUR; DINA MAGDY M. EL-SHEWEHY; SHADIA F. HAMADA; TOSSON A. MORSY. "THE EFFICACY OF THREE MEDICINAL PLANTS: GARLIC, GINGER AND MIRAZID AND A CHEMICAL DRUG METRONIDAZOLE AGAINST CRYPTOSPORIDIUM PARVUM. I- IMMUNOLOGICAL RESPONSE". test, 45, 3, 2015, 559-570. doi: 10.21608/jesp.2015.96295
ABOUEL-NOUR, M., EL-SHEWEHY, D., HAMADA, S., MORSY, T. (2015). 'THE EFFICACY OF THREE MEDICINAL PLANTS: GARLIC, GINGER AND MIRAZID AND A CHEMICAL DRUG METRONIDAZOLE AGAINST CRYPTOSPORIDIUM PARVUM. I- IMMUNOLOGICAL RESPONSE', test, 45(3), pp. 559-570. doi: 10.21608/jesp.2015.96295
ABOUEL-NOUR, M., EL-SHEWEHY, D., HAMADA, S., MORSY, T. THE EFFICACY OF THREE MEDICINAL PLANTS: GARLIC, GINGER AND MIRAZID AND A CHEMICAL DRUG METRONIDAZOLE AGAINST CRYPTOSPORIDIUM PARVUM. I- IMMUNOLOGICAL RESPONSE. test, 2015; 45(3): 559-570. doi: 10.21608/jesp.2015.96295

THE EFFICACY OF THREE MEDICINAL PLANTS: GARLIC, GINGER AND MIRAZID AND A CHEMICAL DRUG METRONIDAZOLE AGAINST CRYPTOSPORIDIUM PARVUM. I- IMMUNOLOGICAL RESPONSE

Journal of the Egyptian Society of Parasitology
Article 11, Volume 45, Issue 3, December 2015, Pages 559-570    PDF (338.1 K)
Document Type: Original Article
DOI: 10.21608/jesp.2015.96295
Authors
MOHAMED F. ABOUEL-NOUR1; DINA MAGDY M. EL-SHEWEHY1; SHADIA F. HAMADA1; TOSSON A. MORSY2
1Department of Zoology, Faculty of Science, Mansoura University, Mansoura, Egypt.
2Department of Parasitology, Faculty of Medicine, Ain Shams University, Cairo 11566, Egypt.
Abstract
Cryptosporidisis parvum is a zoonotic protozoan parasite infects intestinal epithelial cells causing a major health problem for man and animals. Experimentally the immunologic mediated elimination of C. parvum requires CD4+ T cells and IFN-γ. But, the innate immune responses also have a significant protective role in both man and animals. the mucosal immune
response to C. parvum in C57BL/6 neonatal and GKO mice shows a concomitant Th1 and Th2 cytokine mRNA expression, with a crucial role for IFN-γ in the resolution of the infection. NK cells and IFN-γ have been shown to be important components in immunity in T and B cell-deficient mice, but IFN-γ-dependent resistance is demonstrated in alymphocytic mice. Epithelial cells may play a vital role in immunity as once infected these cells have increased expression of inflammatory chemokines and cytokines and demonstrate anti-infection killing mechanisms. C. parvum immunological response was used to evaluate the efficacy of anti-cryptosporidisis agents of Garlic, Ginger, Mirazid and Metronidazole in experimentally infected mice.
Keywords
Anti-cryptosporidisis; Garlic; Ginger; Mirazid; Metronidazole; mice
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