Adverse Effects of Repaglinide Alone and in Combination of Vitamin E | ||
| Benha Veterinary Medical Journal | ||
| Article 36, Volume 35, Issue 2, December 2018, Pages 413-421 PDF (1.4 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/bvmj.2018.96438 | ||
| Authors | ||
| G.A Shams; M.A. Kamel; R.M. Ezzat | ||
| Department of Pharmacology , Faculty of veterinary Medicine ,Zagazig university, Egypt | ||
| Abstract | ||
| The purpose of this study is to investigate the adverse effects of repaglinide. Twenty of male albino rats were randomly divided into four groups (five of each): (i) Control, (ii) Vitamin E (100 mg/kg b.wt) administered orally, (iii) Repaglinide (0.09mg/kg b.wt) administered orally, and (iv) Vitamin E plus repaglinide were administered orally at the same doses. Treatment with Vitamin E and /or repaglinide were continued for 2 successive weeks. At the end of experiment, serum samples were obtained for some biochemical analysis including: catalase (CAT), superoxidase dismutase (SOD), glutathione peroxidase (GPx) and malondialdehyde (MDA). Kidney and liver were taken for histopathological examination. The obtained results showed a significant decrease in the serum level of CAT, SOD, GPx and a significant increase in the level of MDA in repaglinide group compared to the control group. Meanwhile, the group treated with vitamin E plus repaglinide revealed an improvement in the values of antioxidant enzymes compared to rats administered repaglinide group. Liver sections showed a focal co-agulative necrosis with cell aggregation and kidney sections revealed a necrotic glomeruli with destructed hemorrhagic renal tubules in the rats treated with repaglinide. However, rats treated with both vitamin E plus repaglinide illustrated a noticed recovery of liver and kidney tissues. In conclusion, administration of vitamin E can be recommended to overcome side effects associated with repaglinide by its protective antioxidant activity. | ||
| Keywords | ||
| Repaglinide; Diabetes; Antioxidants and Vit. E | ||
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