Effect of Psidium guajava leaf extract, glibenclamide and their combination on rat model of diabetes induced by streptozotocin | ||
| The Egyptian Journal of Hospital Medicine | ||
| Article 6, Volume 72, Issue 6, July 2018, Pages 4610-4619 PDF (254.13 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejhm.2018.9789 | ||
| Authors | ||
| Shadia Ali Radwan1; Omnia Nasr Abdelrhman Mohamed1; Yasser A. Khadrawy2; Gamal Abdel-Aty Hafez3 | ||
| 1Department of Biological and Geological Sciences, Faculty of Education, Ain Shams University | ||
| 2Department of Medical Physiology, Medical Division, National Research Center | ||
| 3Department of pathology, Faculty of medicine- Suez Canal University | ||
| Abstract | ||
| Aim: The present aim is to evaluate the anti-diabetic effect of aqueous extract of guava (Psidium guajava) leaf using rat model of diabetes induced by streptozotocin. In addition, the effect of this extract on liver and kidney functions induced in rat model of diabetes were investigated. Material and Methods: Rats were divided randomly into: control group, rat model of diabetes induced by streptozotocin, rat model of diabetes treated with aqueous extract of guava leaf, rat model of diabetes treated with glibenclamide and rat model of diabetes treated with aqueous extract of guava leaf plus glibenclamide. Result: In the present rat model of diabetes a significant decrease in the serum insulin level and a significant increase in glucose level were detected. Streptozotocin induced a significant increase in the activities of AST, ALT, ALP and a significant increase in the levels of bilirubin, urea, creatinine and uric acid. In addition histopathological and immunological changes were detected in the pancreatic tissue. The present data revealed that aqueous extract of guava leaf improved the reduced insulin level and the high glucose level induced by streptozotocin. This was associated with an improvement in the changes in the liver and kidney functions. Loss of body weight gain induced by streptozotocin was alleviated by guava leaf extract, glibenclamide or both. Conclusion: According to the present findings it could be concluded that the aqueous extract of guava leaf has a potent anti-hyperglycemic effect on rat model of diabetes induced by streptozotocin with hepatic and renal protective effects. | ||
| Keywords | ||
| hypoglycemic; streptozotocin; Psidium guajava; Liver functions; kidney functions; Rats | ||
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