Immunomodulating Efficacy Of Different Adjuvants In Formulation Of Foot And Mouth Disease Vaccine Relative To Its Immunogenicity | ||
| Journal of Applied Veterinary Sciences | ||
| Article 3, Volume 5, Issue 3, July 2020, Pages 14-30 PDF (708.99 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/javs.2020.98318 | ||
| Authors | ||
| El-Sayed E. I.* 1; Mossad W.G.2; Hassanin A. I.3; Shabana W.2 | ||
| 1Department of Foot and Mouth Disease, Veterinary Serum and Vaccine Research Institute, Abbasia, Cairo, Egypt | ||
| 2Department of FMD, Veterinary Serum and Vaccine Research Institute (VSVRI), Abbasia, Cairo, Egypt. | ||
| 3Department of FMD, Veterinary Serum and Vaccine Research Institute (VSVRI), Abbasia, Cairo, Egypt | ||
| Abstract | ||
| The ideal adjuvant is one that able to aid in early stimulation of the humeral immune response, and to promote the production of high antibody titers that would persist for long duration as well as stimulate the cellular immune response. This immunological study was conducted to reveal the aluminum hydroxide gel effect with the use of oil adjuvants on the immune response of polyvalent foot and mouth disease (FMD) vaccine in sheep. Twenty five sheep, were divided to five group (five animals/group) where the 1st group was vaccinated with polyvalent FMD ISA 206 oil vaccine, 2nd group was vaccinated with polyvalent FMD ISA 206 + aluminum hydroxide gel vaccine, 3rd group was vaccinated with polyvalent ISA 201 oil vaccine, 4th group was vaccinated with polyvalent ISA 201 + aluminum hydroxide gel vaccine, 5th group was kept as a negative control (non-vaccinated). Blood and Serum samples were collected from vaccinated animals for monitoring the cellular and humoral immune responses. The results showed that sheep groups immunized with the vaccine prepared with ISA 201with aluminum hydroxide gel is considered the best cellular and humeral immunity post vaccinal response then ISA 201 followed by ISA 206 with aluminum hydroxide gel and the last one is the vaccine prepared with ISA 206 alone.It can be concluded that ISA oils with aluminum hydroxide gel induce the best cellular and humeral immunity. | ||
| Keywords | ||
| FMD vaccine; immune response; Montanide ISA201; Montanide ISA206; aluminum hydroxide gel | ||
| References | ||
|
Abd El- Rahman, A. O., Farag, M. A., Samira El- Kilany, Eman, M. A., Manal Abo El Yazed and Zeidan, S. 2006. Isolation and identification of FMDV during an outbreak of 2006 in Egypt. Kafr El- Sheikh Vet. Med. J.; 4(1).
Abd El-Rhman, M.M., Abo El-Hassan, D.G. and Salem, S.A.H. 2015. Sero survey on current status of foot and mouth disease in some Egyptian governorates, 2013-2015. Egypt. J. Virol., 12(2. 48-56.
Abd El-Rhman MM, Abo El-Hassan DG, Awad WS and Salem SAH 2020. Serological evaluation for the current epidemic situation of foot and mouth disease among cattle and buffaloes in Egypt, Veterinary World, 13(1. 1-9.
Antley, P.P. and Hazen, K.C. 1988. Role of yeast cell growth temperature on Candida albicans virulence in mice. Immunology Journal, 56: 2884-2890.
Aucouturier, J., Dupuis, L. and Ganne, V. 2001. Adjuvants designed for veterinary and human vaccines. Vaccine.19:2666–2672.
Barnett, P., Pullen, L. Williams, L. and Doel, T.R. 1996. Assessment of Montanide ISA 25 and ISA 206, two commercially available oil adjuvant. Vaccine,14(13.1187-1198.
Barnett, P.V., Cox S.J., Aggarwal, N., Gerber, H. and McCullough, K.C. 2002.Further studies on the earlyresponses of pigs following immunizationwith high potency foot and mouth disease vaccine.Vaccine, 19: 3197-208.
Barnett,P.V.; Statham, R.J.; Vosloo, W. and Haydon, D.T. 2003."Foot-and-mouthdisease vaccine potency testing: determination and statistical validation of a model using a serological approach." Vaccine, 21(23.3240-8.
Brewer,J.M., Conacher,M., Satoskar,A., Bluethmann,H. and Alexander,J. 1996. In interleukin-4-deficient mice, alum not only generates T helper 1 responses equivalent to Freund’s complete adjuvant, but continues to induce T helper 2 cytokine production. Eur. J. Immunol. 26, 2062–2066.
Cloete,M., Dungu, B., Van Staden, L., Ismail-Cassim, N. and Vosloo, W.2008. Evaluation ofdifferent adjuvants for foot-and-mouth disease vaccine containing all the SAT serotypes.Onderstepoort J Vet Res. ;75:17–31.
Code of Federal Regulation of USA. 2019. Animal and Animal Products 92019. Office of the Federal Register National Archives and Record Administration.
Daoud HM, Ibrahim EE, El-Din WMG and Hassanin AIH 2013. Preparation of Foot and Mouth Disease trivalent vaccine type A, O, SAT2 and determination of the Guinea pig protective dose 50 (GPPD ), Veterinary World 6(11. 844-851.
Dara P., Kalaivanana R., Sied N., Mamo B., Kishore S., Suryanaraya V.V. and Kondabattula G. 2013.Montanide ISA201 adjuvanted FMD vaccine induces improvedimmune responses and protection in cattle. Vaccine,31:3327–3332.
Depa, P.M., Dimri, U., Sharma, M.C. and Tiwari, R. 2012.Update onepidemiology and control of foot and mouth disease – A menace to international trade and global animal enterprise. Vet. World, 5(11. 694-704.
Dong Li, Chunxue Zhou, Daliang She, Pinghua Li, Pu Sun, Xingwen Bai, Yingli Chen, Baoxia Xie and Zaixin Liu 2013. The comparison of the efficacy of swine FMD vaccine emulsified with oil adjuvant of ISA 201 VG or ISA 206 VG, Journal of Biosciences and Medicines, 1, 22-25, http://dx.doi.org/10.4236/jbm..13005
El-Bagoury, G.F., El-Habbaa, A. S., Gamil, M.A. and Fawzy, H.G. 2014. Evaluation of an inactivated combined oil vaccine prepared for foot and mouth disease and bovine ephemeral fever. Benha Vet. Med. J., 27(1. 221-231.
EL-Naggar, H. 2012. Preparation of inactivated lyophilized NDV vaccine, M.V.Sc in Veterinary Science (Virology). Cairo University.
EL-Sayed E. Ibrahim, Wael Mossad Gamal, Amr Ismail Hassan, Safy El-DinMahdy, Akram Zakria Hegazy and Magdy Mahmoud Abdel-Atty 2015.Comparative study on the immunopotentiator effect of ISA 201, ISA 61, ISA 50, ISA206 used in trivalent foot and mouth disease vaccine .Veterinary World,EISSN:22310916 , P.(1189-1198)
El-Watany, H., Shawky, M., Rhshdy, O.H. and El- Kelany, S. 1999. Relationship between cellular andhumoral immunity responses in animal vaccinatedwith FMD vaccine. Zigzag Veterinary MedicalJournal, 27: 137-143.
Fakhry, H.M., Rizk, S.A., Abu-Elnaga, H.I., Deghaidy, W., Talaat, A.A. and Hegazi, A.Z. 2012. Field application of bivalent foot and mouth disease vaccine adjuvanted with Montanide ISA (25, 50, 206) and IMS (1113-3015) as an alternative to aluminum hydroxide gel. Egypt. J. Virol., 9(1. 123-136
Farag, M.A., Aggour, M. A. and Daoud, A.M. 2005.ELISA as a rapid method for detecting the correlation between the field isolates of FMD and the current used vaccine strain in Egypt.Vet. Med. J. Giza, Vol. 53 no. 4: 949- 955.
Ferreira, M.E.V. 1976. Prubade microneutralization poraestudies de anticueropos de la fibre aftosa. 13th Centropanamericano Fiebre Aftosa, (21/22. 17-24
Food and Agriculture Organization. 2011. The Progressive Control Pathway for FMD Control (PCP-FMD. Principles, Stage Descriptions and Standards. Available from: http:// www.fao.org/ag/againfo/commissions/docs/pcp/pcp26012011.pdf. Last accessed on 20-12-2019.
Franki, R.I.B., Fauquet, C.M., Knudson, D.L. and Brown, F. 1991.Classification and nomenclature of viruses. 5th Report of International Communication on Taxonomy of Viruses, suppl. 2.
Gupta,R.K., Rost,B.E., Relyveld,E. and Siber,G.R. 1995. Adjuvant properties of aluminum and calcium compounds, Pharm. Biotechnol. 6, 229–248.
HAMBLIN,C., BARNETT,I.T.R. AND CROWTHER, J.R 1986.New Enzyme-Linked ImmunoSorbent Assay (ELISA) for the detection of antibodies against FMD virus. П Application. Journal of Immunological Methods, 93: 123-129.
Harmon, B.G. and Glisson, J.R. 1989. In vitro microbial activity of avian peritoneal macrophages. Avian Disease Journal, 33: 177-181.
Hussein, H.A. 1989. Immunosuppressive effect of MDV. B.V.SC, Virology Vet. Thesis, Cairo Univ.
Ismail, A.H., El-Mahdy, S.A., Mossad, W.G., Abd El-Krim, A.S., Abou El-Yazid, M. and Ali, S.M 2013. Optimization of the inactivation process of FMD virus serotype SAT-2 by binary ethyleneimine (BEI). J. Vet, Adv., 3(3. 117-124.
Juleff N. D., Maree, F. F., Waters, R., Bengis, R. G. and Charleston B. 2012. The importance of FMDV localization in lymphoid tissue. Veterinary Immunology and Immuno- pathology, 148:145-148.
Knudsen, R.C., Groocock, C.M. and Aaderson, A.A. 1979. Immunity to foot-and-mouth disease virus in guinea pigs: clinical and immune responses. Infection andImmunity 24: 787-792.
Lee, L.F. 1984. Proliferative response of chicken B and T lymphocyte to mitogen. Veterinary Medicine Journal, 15: 44-52.
Lombard, M., Pastoret, P.P. and Moulin, A.M. 2007. A brief of vaccines and vaccination. Rev. Sci. Tech., 26(1. 29-48.
Longjam, N., Deb, R., Sarmah, A.K., Tayo, T., Awachat, V.B. and Saxena, V.K. 2011. A brief review on diagnosis of foot and-mouth disease of livestock: Conventional to molecular tools. Vet. Med. Int.,: 905768.
Lucy, F.L. 1977. Chicken Lymphocyte stimulation by mitogenes. A microassay with whole blood cultures. Avian Disease, 22: 296-307.
Mayer, S., Falkenrodt, A. and Tongio, M.M. 1974. Anomalous reactivity of sera containing cold lymphocytotoxins with chronic leukemic lymphocytes. Tissue Antigens, 4: 266-270.
Mercedes G. V.,Timothy D., Trevor C., Martin R. and R. Michael E. P. 1996.Recognition of foot-and-mouth disease virus and its capsid protein VP1 by bovine peripheral T lymphocytes.Journal of General Virology, 77, 727-735.
Mossad W. Gamal El-Din, Ehab El-Sayed Ibrahim, Hind Daoud and Samir Mohamed Ali 2014.Humeral and cellular immune response of Egyptian trivalent foot and mouth disease oil vaccine in sheep. Res. Opin. Anim. Vet. Sci., 4(4. 178-185.
Nader M. Sobhy, Sunil K. Mor, Mohammed E.M. Mohammed, Iman M. Bastawecy, Hiam M. Fakhry, and Sagar M. Goyal 2014.Phylogenetic analysis of Egyptian foot and mouth disease virus endemic strains in 2013. 5th International Conference of Virology , Egyptian J. Virol.,Vol. 11 (1) 49-59.
OIE World Organisation for Animal Health .2017. Manual of diagnostic tests and vaccines for terrestrial animals, OIE, Paris. Available at:www.oie.int/en/international-standardsetting/ terrestrial-manual/access-online/ (accessed on 4 August 2018)
Orsel,K.;deJong,M.C.;Bouma,A.;Stegeman,J.A.andDekker,A.2007.Foot and mouth disease virus transmission among vaccinated pigs after exposure to virus shedding pigs. Vaccine 2 21;25(34.6381-91.
Park,J.H.2013. Requirements for improved vaccines against foot-and-mouth disease epidemics. Clin. Exp. Vaccine Res. 2, 8–18.
Park,M.E., Lee,S.Y., Kim,R.H., Ko, M.K., Lee,K.N., Kim,S.M. et al.2014.Enhanced immune responses of foot-and-mouth disease vaccine using new oil/geladjuvant mixtures in pigs and goats. Vaccine, 32, 1882–1889.
Park Min-Eun, Seo-Yong Lee, Rae-Hyung Kim, Mi-Kyeong Ko, Jeong-Nam Park, Kwang-Nyeong Lee, Su-Mi Kim, Joo-Hyung Choi, Su-Hwa You, Byounghan Kim, Jong-Soo Lee b and Jong-Hyeon Park 2016.Altered adjuvant of foot-and-mouth disease vaccine improves immune response and protection from virus challenge. Trials in Vaccinology 5, 97–104.
Patil,P.K., Bayry,J., Ramakrishna,C., Hugar, B., L.D. Misra,L.D. and Natarajan,C. 2002a. Immune responses of goats against foot-and-mouth disease quadrivalent vaccine: comparison of double oil emulsion and aluminium hydroxide gel vaccines in eliciting immunity, Vaccine 20, 2781–2789.
Patil,P.K., Bayry,J., Ramakrishna,C., Hugar,B., Misra,L.D. and Prabhudas,K., 2002b. Immune responses of sheep to quadrivalent double emulsion foot-and-mouth disease vaccines: rate of development of immunity and variations among other ruminants, J. Clin. Microbiol. 40 ,4367–4371.
Paton, D.J., Sumption, K.J. and Charleston, B. 2009.Options for control of foot and-mouth disease: knowledge, capability and policy. Philosophical Transactions of the Royal Society Biological Science B, 364: 2657-2667.
Pattnaik, B., Subramaniam, S., Sanyal, A., Mohapatra, J.K., Dash, B.B. and Ranjan, R. 2012. Foot and mouth disease; global status and future road map for control and prevention in India. Agric. Res., 1(2. 132-147.
Randall, R., Binn, L.N. and Harrison, V.R. (1964. Immunization against Rift Valley fever virus. Studies on the immunogenicity of lyophilized formalin inactivated vaccine. J. Immunol., 92: 293-299.
Reddy,G.S. and Srinivasan,V.A. 1996. Performance of aluminium hydroxide gel and oil adjuvant rabies vaccines in bovines. Zentralbl Bakteriol, 286, 523–526.
Richardson, M.D. and Smith, H. 1981. Resistance of virulent and attenuated strains of Candida albicans to intracellular killing by human and mouse phagocytes. Journal of Infectious Disease, 144: 557-565.
Rimaniol,A.C., AND Gras,G. 2004. Aluminum hydroxide adjuvant induces macrophage differentiation towards a specialized antigen-presenting cell type, Vaccine, 13 (22), 3127–3135.
Rodriguez, L.L. and Grubman, M.J.2009. Foot and mouth disease virus vaccines. Vaccine, 27 Suppl 4: D90-4.
Satya, P. 2009.Vaccination against foot-and-mouth disease virus: Strategies and effectiveness. Expert Rev. Vaccines, 8(3. 347-365.
Sébastien Deville, Juliette Ben Arous, François Bertrand and Laurent Dupuis 2013. MontanideTMadjuvants for stimulation of cellular immuneresponse in FMD vaccines Tech Bull. Paris: Seppic.
Shabana, W. 2014. Preparation of combined oil vaccine against foot and mouth disease and rift valley fever in sheep. PhD. Thesis, Virology Department, Faculty of Veterinary Medicine, Cairo University, Egypt.
Sharma, M.C., Pathak, M.N. Hung, M.N., Nhi D.L. and Vuc, N.V. 1984.Report on the out break of foot and mouth disease in buffaloes in the southern part ofVietnam. Veterinary Viral Diseases : 302–305.
Shawky M., Abd El-Aty M., Hiam. M. Fakry, Hind M. Daoud, Ehab El-Sayed I., Wael Mossad G., Sonia A. Rizk, Abu-Elnaga H., Mohamed A. A., Abd El-kreem A. and Farouk E. M. 2013. Isolation and Molecular Characterization of Foot and Mouth DiseaseSAT2 Virus during Outbreak 2012 in Egypt . J Vet Adv, 3(2. 60-68.
Slater, T.F., Sawyer, B. and Sträuli, U. (1963. Studies on succinate-tetrazolium reductase system: III. Points of coupling of four different tetrazolium salts. Biochemical biophysical Acta, 77: 383-393.
Sobhy, N.M., Mor, S.K., Mohammed, M.E.M., Bastawecy, I.M., Fakhry, H.M., Youssef, C.R.B. and Goyal, S.M. 2014. Phylogenetic analysis of Egyptian foot and mouth disease virus endemic strains. J. Am. Sci., 10(9. 133-138.
Soltan, M.A., Negmaldin, A.H., El-Diasty, M.M., Mansour, S.M.G., Elbadry, M.A. and Wilkes, R.P. 2017. Molecular characterization of circulating foot and mouth disease virus (FMDV) serotype O topotype EA-3 and serotype A (African topotype) genotype IV in Egypt, 2016. Vet. Microbiol., 208: 89-93.
Sonia,A., Rizk, Hiam, M., Fakhry and Abu-Elnaga, H.I. 2010. Comparative study of T cell proliferative response in cattle vaccinated with FMD vaccine using Cell titre Aqueous one solution non radioactive assay (MTS). Zag. Vet. J. (ISSN. 1110-1458) Vol. 38, No. 4 pp. 188-195.
Valdazo-González, B., Kim, J.T., Soubeyrand , S., Wadsworth, J., Knowles, N.J., Haydon, D. and King, D.P. 2015. The impact of within-herd genetic variation upon inferred transmission trees for foot-and-mouth disease virus. Infect., Genet. Evol., 32(1. 440-448.
Voller, A., Bid Well, D. and Bartleha 1976.Micro plate enzyme immuno assay for the immuno diagnosis of virus infection. Am. Soc. For Micro.(506-512).
Wisniewski J., Kobusiewiecz T., Baronowski C., and Jankowsko J., 1972. Determination of the level of immunity in cattle on the basis of neutralizing antibodies after the use of Frenkel type FMD vaccine.Medycyna Wet 28 (10.586-588.
Xuan H., Li Y., Fang, H. and Zheng, C. 2011. Establishment of persistent infection with foot and mouth disease virus in BHK-21 cells. Virol. J., 8: 169.
| ||
|
Statistics Article View: 1,102 PDF Download: 932 |
||
