C:Parameter Optimization of Solid Lipid Nanoparticles Formulation | ||
| Records of Pharmaceutical and Biomedical Sciences | ||
| Article 12, Volume 4, Issue 2, July 2020, Pages 1-7 PDF (470.16 K) | ||
| Document Type: Mini-reviews | ||
| DOI: 10.21608/rpbs.2020.23041.1050 | ||
| Authors | ||
| shimaa gamal salem* 1; ahmed refaat gardouh2; shadeed Gad3 | ||
| 1Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Sinai University, Ismailia, Egypt | ||
| 2pharmaceutics department, faculty of pharmacy, suez canal university | ||
| 3Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt | ||
| Abstract | ||
| Solid lipid nanoparticles (SLN) are colloidal lipid carriers, which used for improving the bioavailability of lipophilic and hydrophilic drugs. SLN are composed of biodegradable lipids such as hard fats, highly purified triglycerides, monoglycerides, complex glyceride mixtures or waxes which are solid at room temperature. In the present study, different formulation variables, including the type and quantity of lipid and surfactant were optimized for the preparation of SLN. SLN were prepared by a modified micro emulsion-based method and their particle size was evaluated. Two types of surfactants Tween 80 and Poloxamer 188 were used. Also, the monoglyceride (Glyceryl monostearate) and wax (Cetyl palmitate) were used as lipid. The optimum SLN formulae were at lipid concentration 5%. The optimum surfactant concentration was 6%. SLN with a surfactant Tween 80 were smaller in size than Poloxamer 188 SLN. Glyceryl monostearate formed a smaller size SLN than Cetyl palmitate. Increasing Glyceryl monostearate concentration in the lipid ratio resulted in the formation of small size SLN. | ||
| Keywords | ||
| solid lipid nanoparticles; modified micro emulsion-based method; high shear homogenization; Tween 80; Poloxamer 188; Glyceryl monostearate; Cetyl palmitate | ||
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