Shoeib, S., Abd ElHalim, A., Abd ElHafez, M., Dawod, A., Abd ElMohsen, E., ElBaz, S. (2020). Serum Soluble Glycoprotein VI (sGPVI) to Predict the 28th Day In-Hospital Mortality in Adult Patients with Sepsis. test, 80(2), 820-826. doi: 10.21608/ejhm.2020.98915
Sabry Abd Allah Shoeib; Ayman Fathy Abd ElHalim; Mohamad Ahmad Abd ElHafez; Ashraf Abd ElRaof Dawod; Essam Ali Abd ElMohsen; Sameh Abo ElNasr Abd ElSalam ElBaz. "Serum Soluble Glycoprotein VI (sGPVI) to Predict the 28th Day In-Hospital Mortality in Adult Patients with Sepsis". test, 80, 2, 2020, 820-826. doi: 10.21608/ejhm.2020.98915
Shoeib, S., Abd ElHalim, A., Abd ElHafez, M., Dawod, A., Abd ElMohsen, E., ElBaz, S. (2020). 'Serum Soluble Glycoprotein VI (sGPVI) to Predict the 28th Day In-Hospital Mortality in Adult Patients with Sepsis', test, 80(2), pp. 820-826. doi: 10.21608/ejhm.2020.98915
Shoeib, S., Abd ElHalim, A., Abd ElHafez, M., Dawod, A., Abd ElMohsen, E., ElBaz, S. Serum Soluble Glycoprotein VI (sGPVI) to Predict the 28th Day In-Hospital Mortality in Adult Patients with Sepsis. test, 2020; 80(2): 820-826. doi: 10.21608/ejhm.2020.98915

Serum Soluble Glycoprotein VI (sGPVI) to Predict the 28th Day In-Hospital Mortality in Adult Patients with Sepsis

The Egyptian Journal of Hospital Medicine
Article 11, Volume 80, Issue 2, July 2020, Pages 820-826    PDF (601.12 K)
Document Type: Original Article
DOI: 10.21608/ejhm.2020.98915
Authors
Sabry Abd Allah Shoeib; Ayman Fathy Abd ElHalim; Mohamad Ahmad Abd ElHafez; Ashraf Abd ElRaof Dawod; Essam Ali Abd ElMohsen; Sameh Abo ElNasr Abd ElSalam ElBaz*
Abstract
Background: Sepsis is a complicated syndrome resulting from the inappropriate expression of host factors in response to infection and is a major cause of death in patients that are hospitalized in emergency departments and in critical care units.
Objective: The purpose of the present study was to identify the role of serum soluble glycoprotein VI (sGPVI) in predicting the 28th day in-hospital mortality in adult patients with sepsis.
Patients and methods: This observational prospective cohort study included a total of 90 adult patients aged ≥18 years old with clinically suspected sepsis, recruited from Medical Intensive Care Units of Menoufia University Hospital and Kafr El-Sheikh general hospital. The included subjects were diagnosed using quick SOFA score and according to survival at the 28th day, they were divided into two groups; Group A (survivors) consisted of 69 patients (76.7%) and Group B (non survivors) consisted of 21 patients (23.3%).
Results: As regard clinico-laboratory data (qSOFA, sGPVI, SGOT, respiratory rate, ESR, WBCs) and complications (hospital stay), they are significantly increased (P value < 0.001) in non-survivor studied patients in comparison with survivor ones. Concerning platelet count, it is significantly reduced (P value < 0.001) in non-survivor studied patients in comparison with survivor ones. As regard clinico-laboratory data (qSOFA, SGOT, respiratory rate, ESR and WBCs) and complications (hospital stay), they are positively correlated with sGPVI with a statistically significant difference in non-survivor studied patients. Concerning platelet count, it is negatively correlated with sGPVI with a statistically significant difference in non-survivor studied patients.
Conclusion: It could be concluded that glycoprotein VI is a valuable prognostic predictor during sepsis being more reliable than other widely used indicators and severity scores, such as qSOFA, WBCs, platelet count and CRP.
Keywords
Sepsis; sGPVI; qSOFA; CRP
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