PROGNOSTIC VALUE OF PD-L1 TUMOR EXPRESSION IN EGYPTIAN PATIENTS WITH EPITHELIAL BLADDER CANCER | ||
| Ain Shams Medical Journal | ||
| Article 14, Volume 70, 10, 11 & 12, July 2019, Pages 715-728 PDF (237.98 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/asmj.2019.101283 | ||
| Authors | ||
| Sherif Ahmed Abdel-Wahab1; Manal Mohamed El Mahdy2; Waleed Abdel-Monem Baioumy1; Dina Ragab Diab1; Sharehan Ibrahim Kotb1 | ||
| 1Department of Clinical Oncology and Nuclear Medicine, Faculty of Medicine, Ain Shams University, Cairo, Egypt. | ||
| 2Department of Pathology Faculty of Medicine, Ain Shams University, Cairo, Egypt. | ||
| Abstract | ||
| Background: Bladder cancer ranks tenth in worldwide cancer incidence. With 550,000 newly diagnosed cases in 2018. It is the 7th most common cancer in men and the 17th most common cancer in women. In Egypt the incidence rate of cancer bladder in (2008-2011) 6.94% in both sexes and (10.7%) among men. Aim of the Work: To study the prognostic value of PD-L1 tissue tumoral expression in Egyptian patients with epithelial bladder cancer and its correlation with the different clinicopathological parameters. Patients and Methods: This is a prospective, single arm, cross sectional study which was carried on newly diagnosed 30 patients with epithelial urinary bladder cancer were identified with follow up for 2 years from (Aug 2017-Sep 2019). At both Clinical Oncology and Nuclear Medicine department Ain Shams university Hospital and Nasser Institute Cancer Centre for researches and treatment (NICC). Results: In our study we confirmed that high PD-L1 expression is correlated with prognosis, as patients with high PD-L1tumor expression cells had lower DFS and OS. The tumor PD-L1 over expression had high significant impact on PFS where patients who had PD-L1overexpression had mean 7.2 months compared to 11.4 months in patients who had low tumor PD-L1 expression (P value=0.004). also had significant impact on OS where patients who had high tumor PD-L1 over expression had mean OS 9.633 months compared to 12.00 months in patients who had low tumor PD-L1 expression, (P value= 0.047). Conclusion: Our study concluded that high expression of PDL1 was associated with low PFS and OS and worst prognosis. | ||
| Keywords | ||
| Urothelial bladder cancer; upper urinary urothelial carcinomas; overall survival; progression free survival | ||
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