EFFECT OF SURFACTANTS TREATED BINDER ON THE PHYSICAL PROPERTIES AND BIOAVAILABILITY OF SULFADIAZINE TABLETS | ||
| Bulletin of Pharmaceutical Sciences Assiut University | ||
| Article 4, Volume 6, Issue 2, December 1983, Pages 295-309 PDF (529.17 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/bfsa.1983.102090 | ||
| Authors | ||
| H. M. El-Sabbagh; M. El-Shaboury; A. T. Nouh; A. H. Abd El-Gawad | ||
| Department of Pharmaceutics, Faculty of Pharmacy, Munsoura University, Mansoura, Egypt | ||
| Abstract | ||
| The effect of untreated gelatin binder along with surfactant treated gelatin on the physical properties of sulfadiazine tablets were studied. Surfactant treated gelatin was found to lower the d.t., and hardness, but increased friability value. Further, the effect of surfactant treated gelatin incorporated in sulfadiazine tablets, on the dissolution rate was studied and was found to be better than untreated ones. Concentration of 2.5% of surfactant proved to be the most convenient in producing tablets with good physical properties and high dissolution rate. The maximum urinary excretion of sulfadiazine and higher physiological bioavailability were observed in case of tablets prepared with surfactant treated gelatin. | ||
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