DETERMINATION OF THE CMC OF SELECTED SURFACTANT SOLUTIONS IN SYSTEMS CONTAINING CHLORAMPHENICOL | ||
| Bulletin of Pharmaceutical Sciences Assiut University | ||
| Article 3, Volume 2, Issue 1, 1979, Pages 27-39 PDF (372.38 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/bfsa.1979.104847 | ||
| Authors | ||
| A. E. Aboutaleb; A. M. Sakr; A. Abdelzaher | ||
| Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt | ||
| Abstract | ||
| The solubility of Chloramphenicol was determined in solutions containing the following non-ionic surfactants: Tween 20, Tween 40, Tween 60, Emulgin C 1000, Emulgin C1500, Myrj 52, Myrj 53 and Myrj 59 together with cetrimide and sodium lauryl sulphate as representative examples for cationic and anionic surfactants. The solubilizing capacity of the different surfactant solutions above and below their CMC values were determined. It was concluded that all these surfactants when present in concentrations less than their CMC failed to enhance the solubility of chloramphenicol. The cationic and anionic surfactants showed the most significant increase in the drug solubility than the non-ionic surfactants above their CMC. The CMC values reported for the different classes of surfactants were found to be slightly different from literature reports. | ||
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