Abdel- Ghaffar, F., El-Elaimy, I., EL. Ghreeb, M., Mohamed, A. (2015). Potentiation of antifibrotic activity of Atacand using grape seed extract (Gervital) in male albino rats. test, 1(1), 1-9. doi: 10.21608/jbaar.2015.105944
Faten Abdel- Ghaffar; Ibrahim A. El-Elaimy; Mona EL. Ghreeb; Azza M. Mohamed. "Potentiation of antifibrotic activity of Atacand using grape seed extract (Gervital) in male albino rats". test, 1, 1, 2015, 1-9. doi: 10.21608/jbaar.2015.105944
Abdel- Ghaffar, F., El-Elaimy, I., EL. Ghreeb, M., Mohamed, A. (2015). 'Potentiation of antifibrotic activity of Atacand using grape seed extract (Gervital) in male albino rats', test, 1(1), pp. 1-9. doi: 10.21608/jbaar.2015.105944
Abdel- Ghaffar, F., El-Elaimy, I., EL. Ghreeb, M., Mohamed, A. Potentiation of antifibrotic activity of Atacand using grape seed extract (Gervital) in male albino rats. test, 2015; 1(1): 1-9. doi: 10.21608/jbaar.2015.105944

Potentiation of antifibrotic activity of Atacand using grape seed extract (Gervital) in male albino rats

Journal of Bioscience and Applied Research
Article 1, Volume 1, Issue 1, March 2015, Pages 1-9    PDF (5.09 M)
Document Type: Original Article
DOI: 10.21608/jbaar.2015.105944
Authors
Faten Abdel- Ghaffar* 1; Ibrahim A. El-Elaimy1; Mona EL. Ghreeb1; Azza M. Mohamed2
1Department of Zoology, Faculty of Science, Menoufia University, Shebin El- Kom, Egypt
2Department of Therapeutic Chemistry, National Research Center, Dokki. Egypt
Abstract
Carbon tetrachloride (CCl4) is a known potent hepatotoxic agent. The present investigation clarified the ameliorative effects of Atacand and Gervital on CCl hepatotoxicity. 24 male albino rats were divided into 4 groups, 6 rats each. Group I, served as normal control. Group II, animals were injected subcutaneously with CCl (1ml/kg b.w.) twice a week for 90 days. Group III, rats were injected with CCl4, as Group II, then treated orally with Atacand (8mg/kg b.w.), daily, for 30 days. rats were injected with the same dose of CCl then treated with Atacand (8mg/kg b.w.) along with Gervital (100mg/kg b.w.), orally, daily for 30 days. treatment showed a marked deterioration of liver function as a high increase in the levels of serum AST and ALT (153.8% and 157.8%, respectively). Also, a significant decrease in liver antioxidant machinery was represented by reduced glutathione (GSH, 68.1%), glutathione transferase (GST, 69.9%), and glutathione reductase (GR, 65.65%). On the other side, the levels of liver protein carbonyl groups (PCO) and lipid peroxidation (LPO) were elevated 439.6% and 258.7%, respectively, compared to their control groups. These results indicated the damage as a result of CCl4-induced liver fibrosis. Both treatments with Atacand or Atacand + Gervital showed a significant ameliorative effect for both liver and serum CCl4-induced alterations. The current study recorded the treatment with Gervital along with Atacand antifibrotic effectiveness than that of Atacand Gervital acted as a potentiator for the antifibrotic activity of Atacand.
Keywords
Atacand; Carbon tetrachloride; Gervital; Liver function; Oxidative stress
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