Abd al aziz, S., Soliman, H., Abdel raheim, S., Okasha, A., Abdalla, N. (2014). ASSESSMENT OF SERUM INTERLEUKIN-10 LEVEL IN CHRONIC HEPATITIS C PATIENTS TREATED WITH PEGYLATED INTERFERON AND RIBAVIRIN. test, 12(2), 129-151. doi: 10.21608/kvmj.2014.110156
S. Z. Abd al aziz; Hannan A. Soliman; S. R., Abdel raheim; A. M. Okasha; Nilly Helmy Abdalla. "ASSESSMENT OF SERUM INTERLEUKIN-10 LEVEL IN CHRONIC HEPATITIS C PATIENTS TREATED WITH PEGYLATED INTERFERON AND RIBAVIRIN". test, 12, 2, 2014, 129-151. doi: 10.21608/kvmj.2014.110156
Abd al aziz, S., Soliman, H., Abdel raheim, S., Okasha, A., Abdalla, N. (2014). 'ASSESSMENT OF SERUM INTERLEUKIN-10 LEVEL IN CHRONIC HEPATITIS C PATIENTS TREATED WITH PEGYLATED INTERFERON AND RIBAVIRIN', test, 12(2), pp. 129-151. doi: 10.21608/kvmj.2014.110156
Abd al aziz, S., Soliman, H., Abdel raheim, S., Okasha, A., Abdalla, N. ASSESSMENT OF SERUM INTERLEUKIN-10 LEVEL IN CHRONIC HEPATITIS C PATIENTS TREATED WITH PEGYLATED INTERFERON AND RIBAVIRIN. test, 2014; 12(2): 129-151. doi: 10.21608/kvmj.2014.110156

ASSESSMENT OF SERUM INTERLEUKIN-10 LEVEL IN CHRONIC HEPATITIS C PATIENTS TREATED WITH PEGYLATED INTERFERON AND RIBAVIRIN

Kafrelsheikh Veterinary Medical Journal
Article 8, Volume 12, Issue 2, October 2014, Pages 129-151    PDF (819.43 K)
Document Type: Original Article
DOI: 10.21608/kvmj.2014.110156
Authors
S. Z. Abd al aziz* 1; Hannan A. Soliman1; S. R., Abdel raheim2; A. M. Okasha2; Nilly Helmy Abdalla3
1Department of chemistry, Faculty of Science, Beni-Suef University
2Department of Biochemistry, Faculty of Medicine, Minia University, Egypt
3Department of Internal Medicine, Faculty of Medicine, Beni-Suef University
Abstract
Hepatitis C virus (HCV) infection is a major health problem. Egypt has the highest prevalence worldwide. Currently, combined pegylated interferon and ribavirin therapy is the standard treatment but the outcome is not satisfactory. The present study aimed To assess the possible association of serum IL-10 level, SOD activity in erythrocyte lysate and plasma MDA level and response to combined interferon α-2a and ribavirin therapy in chronic HCV infection.
In (Group < /em> I) who were not responded to pegylated interferon and rebavirin combination therapy  we found the level of serum IL-10 and plasma MDA still high while antioxidant enzyme SOD activity reduced. While in (Group II) who responded to pegylated interferon and rebavirin combination therapy a circulating serum IL-10 and plasma MDA levels reduced but erythrocyte antioxidant enzyme SOD activity increased. 
Keywords
chronic hepatitis C; IL-10; pegylated interferon
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