RELATION OF LACTOBACILLI ACIDOPHILUS TO OBESITY IN EGYPTIAN POPULATION | ||
| Journal of the Egyptian Society of Parasitology | ||
| Article 6, Volume 50, Issue 2, August 2020, Pages 258-264 PDF (937.57 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/jesp.2020.113043 | ||
| Authors | ||
| RASHA SAMIR MOHAMED1; MAHA ABDELAZIZ AHMED ELTOUNY1; GEORGE SAFWAT RIAD1; HANY NASER ABBAS HANY2 | ||
| 1Department of Internal Medicine | ||
| 2Faculty of Medicine, Ain Shams University, Cairo 11566, and Kafr El-Shiekh General Hospital, MOH | ||
| Abstract | ||
| Current considerations are existed about the sharing role of gut microbiota in the enhancement of obesity and allied comorbidities. This observational case-control study assessed the possible relation of Lactobacilli acidophilus to obesity in a sample of Egyptian population by real-time PCR in stool. The study enrolled 20 healthy slim subjects and 40 subjects who had BMI >25 kg/m2. Routine laboratory analysis and identification of stool L. acidophilus by quantitative real time PCR technique was performed for all enrolled subjects. Lactobacillus acidophilus was expressed in 21/40 (52.5%) fecal samples of obese cases and 16/20 (80%) of fecal samples of nonobese ones. In rest of samples in both groups, the expression was below the detection limit. The results showed that the mean lactobacilli CT was expressed in obese cases (38.89±2.57) compared to (36.08±4.63) in non-obese cases, with high significant difference (P =0.04). Lactobacillus acidophilus was significantly lowered in obese Egyptian patients. The argument about significance correlation between imbalance in gut microbiota and obesity is one of the hot topics in medicine. | ||
| Keywords | ||
| Obesity; Gut Dysbiosis; Lactobacilli acidophilus | ||
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