Hepatoprotective Effect of Moringa oleifera Leaves and Seeds Powder on Carbon Tetrachloride Induced Hepatotoxicity in Rats | ||
| Alexandria Science Exchange Journal | ||
| Article 6, Volume 41, July-September - Serial Number 3, September 2020, Pages 371-379 PDF (498.94 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/asejaiqjsae.2020.115132 | ||
| Author | ||
| Suzan A. Abushal* | ||
| Food Science and Nutrition Department, Turabah University College, Taif University Kingdom of Saudi Arabia Ministry of Education Corresponding author: E.mail; S.aboshal@tu.edu.sa E. mail: sozanabushal@yahoo.com | ||
| Abstract | ||
| The main objective of this study was to investigate the effect of supplementing CCL4-exposed male Sprague Dawley albino rats with 10 and 5% leaves and seeds powder of Moringa oleifera Lam (Moringaceae, M. oleifera) respectively on liver functions. The experiment was carried out on 40 male Albino rats divided into 5 equal groups; 1st group fed on basal diet and kept as a (control-). Rats in the other four groups (n=32) were intoxicated by subcutaneous injection of CCl4 (2ml/kg) twice a week for two consecutive weeks to induce hepatic chronic damage, then those rats were subdivided into: a group that control positive (control+) [2nd group], a group that fed on basal diet + Moringa oleifera leaves powder 10% [3rd group]; a group that fed on basal diet + Moringa oleifera seeds powder 5% [4th group]; a group that fed on basal diet + silymarin whereas silymarin-treated was orally administrated with silymarin 50 mg/kg [5th group]. The results showed that the total cholesterol, triglycerides, LDL-C, AST, ALT, and urea levels decreased significantly with treated rats with Moringa oleifera powder, and the best result was belonged to the group of rats that fed on Moringa oleifera leaves 10%. It can be concluded that, supplementation with high percentage of Moringa oleifera exerts a positive impact on the liver functions, lipid profile and other biochemical parameters. | ||
| Keywords | ||
| Moringa oleifera; Antioxidants; biochemical parameters; Rats | ||
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