The effect of dexamethasone on postoperative blood glucose levels in diabetic and nondiabetic Patients who are undergoing laparoscopic cholecystectomy | ||
| SVU-International Journal of Medical Sciences | ||
| Article 5, Volume 3, Issue 1, January 2020, Pages 19-24 PDF (271.09 K) | ||
| Document Type: Original research articles | ||
| DOI: 10.21608/svuijm.2020.123735 | ||
| Authors | ||
| Ayman H. Mohammed; Mahmoud M. A. Ismail; Hatem S. Mohammed | ||
| Department ofAnesthesiology and Intensive Care and pain management, Faculty of Medicine, South Valley University, Qena, Egypt | ||
| Abstract | ||
| Background: Dexamethasone is a potent corticosteroid when administered alone or in combination.Alone has proven efficacious in preventing nausea and vomiting (PONV) perioperative. However, the administration of even a single dose has been associated with hyperglycemia. Objectives: This is a study that evaluates the effect of 8 mg dexamethasone on blood glucose concentrations among diabetics and non-diabetics in patients who are undergoing laparoscopic cholecystectomy. Patients and Methods: After obtaining ethical clearance 60 American Society of Anesthesiologists I and II patients undergoing laparoscopic cholecystectomy aged 18 to 65 years of either gender with body mass index <30 kg/m2 scheduled for elective laparoscopic cholecystectomy under general anesthesia will be included in the study .patients will be divided into two groups: Group A, 30 diabetic patients receiving 8 mg dexamethasone and group B, 30 non-diabetic patients receiving 8 mg dexamethasone. Blood glucose level will be estimated at 0, 6h, 12h, and 24h. Results: The baseline blood glucose values were higher in diabetics compared to nondiabetics (125.77±22.55 vs. 95.47±15.45 mg/dL). Throughout the study period, blood glucose was significantly higher in diabetic than in non-diabetic patients. All patients in the study who received dexamethasone had significantly higher blood glucose levels subsequently. The rise of blood glucose from baseline was compared between the diabetic and non-diabetic groups at T6 and T12.the rise of blood glucose was similar in both diabetics and non-diabetics at T6. However, at T12, the non-diabetic patients had statistically significant rise in blood glucose levels in comparison with diabetics. Conclusion: The maximum rise in blood glucose was in the range of 40–45 mg/dl in the patients. The clinician should use his clinical judgment before administering dexamethasone for PONV prophylaxis/treatment. | ||
| Keywords | ||
| Dexamethasone; diabetes mellitus; hyperglycemia; postoperative nausea and vomiting | ||
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