Male Breast Cancer: A Retrospective Study | ||
| The Egyptian Journal of Hospital Medicine | ||
| Article 2, Volume 68, Issue 3, July 2017, Pages 1308-1315 PDF (323.1 K) | ||
| Document Type: Original Article | ||
| DOI: 10.12816/0039667 | ||
| Authors | ||
| Hatem Mohamed Abdallah; Ramy Refaat Youssef Ghali; Mai Mohamed Ali Ezz El Din; Hesham Mahmoud Elshimy* | ||
| Clinical oncology department, Ain Shams University | ||
| Abstract | ||
| Background: The male breast cancer (MBC) is a rare disease and represents less than 1% of all malignancies in men and less than 1% of all breast cancers incident. Aim of study: In this descriptive retrospective study we aimed to provide clinico-epidemiological characteristics of MBC. To present the treatment given with respect to DFS , TTP & OS, to identify possible prognostic factors of the disease and the toxicities encountered by the treatment given. Patients and Method: Out of 11313 cancer patients 3046 were breast cancer; 28 of them were MBC. All patients presented to clinical oncology department in Ain Shams University in the period from January 2008 to December 2014 and follow up till December 2016 Results: The median age of patients was 59 years. Around 90% had hormone receptor positive (estrogen and/or progesterone receptors).Two third of the patients had advanced T-stage (T3 and T4). Infiltrating ductal carcinoma the most common type of histology was encountered. Modified radical mastectomy was the most common (75%) type of surgery done followed by chemotherapy for 21 patients and loco-regional radiotherapy for 20 patients. Tamoxifen was administered in 19 patients. Relapse occurred in 14 patients (50%). The 5-year disease-free survival (DFS) was 21.4%, the 5-year time to progression (TTP) rate was 21.4% and the 5-year old overall survival (OS) rate was 35.7%. Conclusion: There is always a delay in the male patients since the first complaint until they seek medical advice, which results in an advanced disease at presentation. | ||
| Keywords | ||
| Male breast cancer; Female breast cancer; BRCA gene; tamoxifen; Aromatase inhibitor | ||
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