A.T., K., M, E., Y.A, A. (2020). Effect of Selenium nanoparticles in wound healing. test, 16(1), 160-168. doi: 10.21608/blj.2020.146617
Keshta A.T.; Emam M; Attia Y.A. "Effect of Selenium nanoparticles in wound healing". test, 16, 1, 2020, 160-168. doi: 10.21608/blj.2020.146617
A.T., K., M, E., Y.A, A. (2020). 'Effect of Selenium nanoparticles in wound healing', test, 16(1), pp. 160-168. doi: 10.21608/blj.2020.146617
A.T., K., M, E., Y.A, A. Effect of Selenium nanoparticles in wound healing. test, 2020; 16(1): 160-168. doi: 10.21608/blj.2020.146617

Effect of Selenium nanoparticles in wound healing

Biochemistry Letters
Article 13, Volume 16, Issue 1, 2020, Pages 160-168    PDF (645.13 K)
Document Type: Original Article
DOI: 10.21608/blj.2020.146617
Authors
Keshta A.T.1; Emam M2; Attia Y.A3
1Assistant professor of Biochemistry, Chemistry Department, Faculty of Science, Zagazig university
2Biochemistry division, Chemistry Department, faculty of Science, Zagazig Univeristy.
3Assistant professor of Physical chemistry, National Institute of Laser Enhanced Sciences, Cairo University
Abstract
Background: Wound healing is a complex process necessary to repairing damaged tissues and preventing infection. Selenium nanoparticles were known by their antioxidant and antimicrobial effect that is important in wound healing. Aim: the aim of this study was to investigate the effect of selenium nanoparticles in reducing and accelerating the wound healing time in mice. Methods: Se NPs were synthesized by a simple wet chemical method. Then the experimental animals were divided into the following groups: Negative control group, Positive control group, selenium nanoparticles control group, wounded mice treated with selenium nanoparticles group. At the end of experiment, mice were scarified&  skin tissue samples were collected for biological analysis [Vascular Endothelial cell Growth Factor, Collagenase I and Nitric oxide] and histopathological study. Results: The results showed that the percentage of wound area has been significantly reduced in Se NPs treated group compared to the positive control. The level of Vascular Endothelial Growth Factor and Collagenase I in Se NPs groups were significantly increased compared to positive control while nitric oxide was significantly decreased in Se NPs treated group. Skin tissue showed effect of selenium nanoparticles by regenerating and recavering skin layer. Conclusion: Selenium nanoparticles have an important role in accelerating and reducing wound healing time.
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