Helal, E., Abou- Aouf, N., Mohamed, N., Taha, N. (2014). Effect of Noise and Crowding Stresses on Hypothalamic–Pituitary–Gonadal Axis and Protective Effect of Sulpiride Drug in Adult Female Albino Rats. test, 56(1), 333-344. doi: 10.21608/ejhm.2014.15692
Eman G. E. Helal; Noran Ahmed Abou- Aouf; Nareman Y. Mohamed; Neama M. Taha. "Effect of Noise and Crowding Stresses on Hypothalamic–Pituitary–Gonadal Axis and Protective Effect of Sulpiride Drug in Adult Female Albino Rats". test, 56, 1, 2014, 333-344. doi: 10.21608/ejhm.2014.15692
Helal, E., Abou- Aouf, N., Mohamed, N., Taha, N. (2014). 'Effect of Noise and Crowding Stresses on Hypothalamic–Pituitary–Gonadal Axis and Protective Effect of Sulpiride Drug in Adult Female Albino Rats', test, 56(1), pp. 333-344. doi: 10.21608/ejhm.2014.15692
Helal, E., Abou- Aouf, N., Mohamed, N., Taha, N. Effect of Noise and Crowding Stresses on Hypothalamic–Pituitary–Gonadal Axis and Protective Effect of Sulpiride Drug in Adult Female Albino Rats. test, 2014; 56(1): 333-344. doi: 10.21608/ejhm.2014.15692

Effect of Noise and Crowding Stresses on Hypothalamic–Pituitary–Gonadal Axis and Protective Effect of Sulpiride Drug in Adult Female Albino Rats

The Egyptian Journal of Hospital Medicine
Article 8, Volume 56, Issue 1, July 2014, Pages 333-344    PDF (493.96 K)
Document Type: Original Article
DOI: 10.21608/ejhm.2014.15692
Authors
Eman G. E. Helal* 1; Noran Ahmed Abou- Aouf1; Nareman Y. Mohamed2; Neama M. Taha3
1Zoology Department, Faculty of Science for Girls Al-Azhar University
2Medical Biochemistry Department , Faculty of Medicine for Girls Al-Azhar University, Egypt
3Physiology Department, College of Medicine, Umm Al-Qura University KSA
Abstract
Background: Noise and crowdingare the most stressful factors which cause depressant effects on human beings, especially females.Therfore this study was aimed at clarifying their effects on hypothalamus pituitary gonadal axis hormones (luteinizing hormone (LH) and follicle-stimulating hormone (FSH), estrogen (E2)and progesterone  as well as prolactin (PRL)and the possible protective effect of antidepressant drug;sulpiride.
 Material and Methods: Sixty adult female rats were divided into six groups (10/each):
1- Rats served ascontrol, 2- Rats treated with sulpiride drug only, 3- Rats exposed to noise (90db, 3hr. per day) for 45 days, 4- Rats exposed to noise and treated with sulpiride drug, 5- Rats exposed to crowding and 6- Rats exposed to crowding and treated with sulpiride drug.
Results: Noise and crowding stresses caused a significant decrease of estrogen (E2), progesterone (P), LH and FSH levels and high significant increase in PRL level. Sulpiride drug   ameliorated these parameters changes except PRL level which showed a high significant level compared to control group.
Conclusion: it is useful to use antidepressant drug (e.g. sulpiride)  with   people who are exposing to noise and   crowding stress.
 
Keywords
Noise; crowding; Sulpiride drug; hypothalamic–pituitary–gonadal axis FSH; LH; PL estrogen; and progesterone
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