Synthesis Strategies and Biological Value of Pyrrole and Pyrrolopyrimidine | ||
| Journal of Advanced Pharmacy Research | ||
| Reviewers, Volume 1, Issue 1, January 2017, Pages 1-24 PDF (3.48 M) | ||
| DOI: 10.21608/aprh.2017.16155 | ||
| Authors | ||
| Mosaad Mohamed; Rania Abd El-Hameed; Amira Sayed* | ||
| Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Helwan University, Ain Helwan, Cairo, Egypt. | ||
| Abstract | ||
| For several decades, interest in the synthesis pyrrole and pyrrolopyrimidine increases due to the importance of these heterocycles both from chemical and biological points of view. They possess several biological activities such as anti-microbial, analgesic, anti-inflammatory, anti-cancer, anti-viral, anti-convulsant, anti-hyperlipidemic, anti-depressant, anti-diabetic, anti-allergic activities. These findings motivated us to present this review which highlights different methods of the synthesis of pyrrole and pyrrolopyrimidine derivatives as well as their biological importance from the past to recent years. | ||
| Keywords | ||
| analgesic; Anti-allergic; Anti-cancer; Anti-convulsant; anti-depressant; anti-diabetic; Anti-hyperlipidemic; Anti-inflammatory; anti-microbial; Anti-viral; 7-deazapurine; Knorr pyrrole synthesis; Paal Knorr; pyrrole; Pyrrolopyrimidine; Synthesis | ||
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