Impact of the treatment with praziquantel and cisplatin on some biochemical parameters after Schistosoma mansoni infection and Ehrlich ascetic carcinoma in mouse model: Thesis Abstract | ||
| Egyptian Journal of Cancer and Biomedical Research | ||
| Article 30, Volume 5, Issue 1.1, May 2021, Pages 28-28 PDF (192.73 K) | ||
| Document Type: Essay Abstract | ||
| DOI: 10.21608/jcbr.2021.61969.1173 | ||
| Authors | ||
| Afnan El-Gowily* 1; Afrah Salama2; Mohamed Labib Salem3 | ||
| 1Biochemistry Division, Chemistry Department, Faculty of Science, Tanta University, Egypt | ||
| 2Chemistry Department, Biochemistry section, Faculty of science Tanta University, Egypt | ||
| 3Immunology and Biotechnology Division, Department of Zoology, Faculty of Science, Tanta University, Egypt | ||
| Abstract | ||
| Thesis Abstract Infections with S. mansoni considers a potential factor for developing cancers in different parts of the human body. This study evaluates the efficacy of cisplatin and its possible role as a complementary medicine with the anti- schistosomal drug; PZQ. Mice were infected with (40-50) S. mansoni cercariae then, after 35 days of infection, mice were (i.p.) injected with 1x106cells/mouse of EAC cells. Mice groups were divided as following ; GP I (control), GP II ( S. mansoni infected alone), GP III (inoculated EAC alone), GP IV (S. mansoni/EAC alone) , GP V (S. mansoni/EAC treated with PZQ) , GP VI (S. mansoni/EAC treated with cisplatin10μg), GP VII (S. mansoni/EAC treated with cisplatin40μg), GP VIII (S. mansoni/EAC treated with PZQ with cisplatin10μg) and GP IX (S. mansoni/EAC treated with PZQ with cisplatin40μg). Worm burden, eggs were counted. Also, tumor volume, total tumor cell counts were measured. We assessed liver and kidney function tests, otherwise we evaluate oxidative and antioxidant parameters. Our data showed worm burden and egg counts were decreased in single cisplatin treated groups and the tumor cell counts in cotreated groups. Also, Hepatic GSH, GST were improved in co treated groups with PZQ than single ones, while hepatic toxicity parameters were decreased. Overall, we concluded that cisplatin even at low doses has anti-schistosomal effects. Also, PZQ co-administration with cisplatin doses ameliorated the level of GSH, it involves the maintenance of antioxidant capacity in protecting the hepatic tissue against oxidative stress by scavenging the very reactive hydroxyl and peroxyl radicals. | ||
| Keywords | ||
| Antioxidant; Cisplatin; Ehrlichs sscites carcinoma; Praziquantel; Schistosomiasis | ||
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