Development of an Ecological-friendly Method for Dexamethasone Determination and Cloud Point Extraction in pharmaceutical formulations using Schiff Base Reaction | ||
| Egyptian Journal of Chemistry | ||
| Article 39, Volume 64, Issue 9, September 2021, Pages 5083-5092 PDF (509.53 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejchem.2021.64886.3390 | ||
| Authors | ||
| Safaa A. Dadoosh1; Mohammed Z. Thani* 2; Asmaa M. Abdullah2; Abbas S. Fahad2; Younus S. Fahad3 | ||
| 1Department of Chemistry, College of Science, Diyala University Diyala, Iraq | ||
| 2Department of Chemistry, College of Science, Al-Mustansiriyah University, Baghdad-Iraq. | ||
| 3State Company for Mining Industries, Baghdad -Iraq | ||
| Abstract | ||
| In this work, new spectrophotometric techniques development for assessment of dexamethasone are described. The first technique including conversion of dexamethasone to colored compound with 2, 4-DNPH as reagent in the acidic medium. The colored compound has a yellow color with absorbance at 405 nm. Between the range of concentration ( 5.0-40 mg.L-1) , The beer,s law is obeyed with correlation coefficient as ( 0.9959), LOD as 0.507 mg.L-1, LOQ as 1.5 mg.L-1. Secondly, in the first technique accompanied by measurement with a UV-Visible spectrophotometer, the CPE technique was used to determine the quantity of the color compound. The linearity of calibration curve was above the range of ( 0.5-6.0 mg.L-1), R2 was 0.9974. LOD and LOQ were found to be 0.108 and 0.354 mg.L-1 respectively. This technique was successfully utilized for dexamethasone detection in the several pharmaceutical formulations by REC% was rang between ( 98-101). | ||
| Keywords | ||
| Dexamethasone; cloud point extraction; Schiff base; Ecological – friendly and 2; 4-dinitrophenylhydrazine | ||
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