Urinary MicroRNA96 as Biomarkers for Bladder Cancer Detection | ||
| Benha Journal of Applied Sciences | ||
| Article 46, Volume 6, Issue 1, January and February 2021, Pages 291-293 PDF (259.46 K) | ||
| Document Type: Original Research Papers | ||
| DOI: 10.21608/bjas.2021.169132 | ||
| Authors | ||
| A.H. Attia1; O.A. Abdullah1; M.A. Hassanien2; S.K. Eliwa1; H.E. Ahmed1 | ||
| 1Biochemistry & Molecular Biology Dept., Faculty of Medicine, Benha Univ., Benha, Egypt | ||
| 2Urology Dept., Faculty of Medicine, Benha Univ., Benha, Egypt | ||
| Abstract | ||
| Bladder malignancy is viewed as the fifth most basic disease with expanded disorder and demise. As of late, incessant examinations showed that microRNAs are arising as indicative biomarkers for bladder malignancy. Explicit miRNA profiles have been distinguished for a few examples from patients with bladder malignancy. MicroRNAs are noncoding RNA particles of around 23 nucleotides that assume significant parts in different strides during the movement of bladder malignant growth. Here, we audit the declaration of miRNAs and their organic capacities, guideline, and clinical ramifications in bladder malignant growth. Either downregulation or upregulation of miRNAs happens in bladder malignant growth through epigenetic changes or imperfections of the biogenesis mechanical assembly. Liberation of miRNAs is engaged with cell cycle capture, apoptosis, multiplication, metastasis, drug obstruction, and different capacities in bladder malignancy. Various miRNAs, have been related with tumor type, stage, or patient endurance, and miRNAs may be created as demonstrative or prognostic markers. A superior comprehension of the jobs of miRNAs in bladder malignant growth will reveal insight into the sub-atomic systems of bladder disease. | ||
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