The comparative effect of chronic allergic dermatitis on the level of pro-inflammatory cytokines in horses and donkeys | ||
| Mansoura Veterinary Medical Journal | ||
| Articles in Press, Accepted Manuscript, Available Online from 14 June 2021 | ||
| Document Type: Original Articles | ||
| DOI: 10.21608/mvmj.2021.70465.1052 | ||
| Author | ||
| Heba Adel Moharam* | ||
| internal medicine and infectious diseases, faculty of veterinary medicine, Mansoura university, Mansoura, Egypt | ||
| Abstract | ||
| Allergic skin disease in the horse is a relatively common clinical presentation. Interleukin-1 super family is a group of cytokines that play a role in the regulation of immune and inflammatory responses. Interleukin (IL)-1β has an important role in the development of allergic diseases. Interleukin-1b (IL-1b) is a potent proinflammatory cytokine, which is involved in many inflammatory conditions including autoinflammatory and allergic disorders. Tumor necrosis factor-alpha (TNF) is a pleiotropic cytokine, which is thought to play a major role in the pathogenesis of inflammatory diseases, including allergy. This study aimed to evaluate the comparative effect of chronic allergic dermatitis on proinflammatory cytokines in horses and donkeys. A total number of fourty five horses (age, 1-10 years old) and fourty five native breed donkeys (age, 1-12 years old) were included in this study. From which 35 horses and 35 donkeys exhibited the clinical signs of chronic allergic dermatitis. In addition, 10 apparently healthy horses and 10 apparently healthy donkeys were selected as a control group for this study. Concerning the serum level of interleukin 1 beta there was a significant increase (p < 0.05) of IL 1b in horses and donkey with allergic dermatitis diseases compared to control group. As well as there was a significant increase (p < 0.05) of TNFα in horses and donkeys with allergic dermatitis diseases compared to control group. The results suggest that an interrelationship exists among allergic dermatitis and inflammatory cytokines in horses and donkeys. | ||
| Keywords | ||
| allergic dermatitis; interleukin-1 beta; tumor necrosis factor α | ||
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