Sarhan, W., Shalaby, S., Zidan, N., Elhawary, A., Ismail, N., Makani, V., Abd elnour, H. (2021). Cytokine Storm in COVID-19 Patients: Association between cytokines and disease severity. test, 27(6), 1640-1653. doi: 10.21608/zumj.2021.76794.2237
Walaa M. Sarhan; Sally M Shalaby; Nahla Zidan; Abeer Elhawary; Nagwan Ismail; Vishruti Makani; Hanim Magdy Abd elnour. "Cytokine Storm in COVID-19 Patients: Association between cytokines and disease severity". test, 27, 6, 2021, 1640-1653. doi: 10.21608/zumj.2021.76794.2237
Sarhan, W., Shalaby, S., Zidan, N., Elhawary, A., Ismail, N., Makani, V., Abd elnour, H. (2021). 'Cytokine Storm in COVID-19 Patients: Association between cytokines and disease severity', test, 27(6), pp. 1640-1653. doi: 10.21608/zumj.2021.76794.2237
Sarhan, W., Shalaby, S., Zidan, N., Elhawary, A., Ismail, N., Makani, V., Abd elnour, H. Cytokine Storm in COVID-19 Patients: Association between cytokines and disease severity. test, 2021; 27(6): 1640-1653. doi: 10.21608/zumj.2021.76794.2237

Cytokine Storm in COVID-19 Patients: Association between cytokines and disease severity

Zagazig University Medical Journal
Article 752, Volume 27, Issue 6, November 2021, Pages 1640-1653    PDF (1.18 M)
Document Type: Original Article
DOI: 10.21608/zumj.2021.76794.2237
Authors
Walaa M. Sarhan* 1; Sally M Shalaby2; Nahla Zidan3; Abeer Elhawary4; Nagwan Ismail5; Vishruti Makani6; Hanim Magdy Abd elnour7
1Medical Biochemistry & Molecular Biology department, Faculty of Medicine, Zagazig University
2Medical Biochemistry Department-Faculty of Medicine- Zagazig University-Egypt
3Clinical Pathology Department, Faculty of Medicine, Zagazig University
4Chest Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt
5Chest Department, Faculty of Medicine, Zagazig University
6Process Development Scientist, KBI Biopharma, Durham, NC, US
7medical biochmestry and molecular biology department, faculty of medicine, Zagazig univerisity, Zagazig, Egypt
Abstract
Objectives: To determine the cytokine storm profile in patients with COVID-19 infection in relation to the disease severity.
Methods: Serum levels of TNF-α, IFN-γ, IL-6 and IL-1β were measured by ELISA method and IL-1RII, TNFR1 and TNFR2 gene expression in peripheral blood mononuclear cells (PBMCs) were done using real time polymerase chain reaction (PCR) method in a total of 203 COVID-19 patients. The 1st group included 52 COVID-19 severe cases, the 2nd comprised 104 moderate cases and the 47 mild cases lied in the 3rd group.
Results: There was a significant association between degree of COVID-19 severity and IL6, TNF-α & IFN-γ serum levels (p < /p>
Keywords
COVID-19; interferon-γ (IFN-γ); Tumor Necrotizing Factor α (TNF-α); Interleukin 6 (IL-6); Cytokine receptors
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