El-Tamany, E., Ali, I., Soliman, H., Fouad, S. (2015). Synthesis and Antimicrobial Activity of some new Benzocoumarin Amino Acid Derivative. test, 13(1), 53-56.
El-Sayed El-Tamany; Ibrahim Ali; Hamdy Soliman; Sally Fouad. "Synthesis and Antimicrobial Activity of some new Benzocoumarin Amino Acid Derivative". test, 13, 1, 2015, 53-56.
El-Tamany, E., Ali, I., Soliman, H., Fouad, S. (2015). 'Synthesis and Antimicrobial Activity of some new Benzocoumarin Amino Acid Derivative', test, 13(1), pp. 53-56.
El-Tamany, E., Ali, I., Soliman, H., Fouad, S. Synthesis and Antimicrobial Activity of some new Benzocoumarin Amino Acid Derivative. test, 2015; 13(1): 53-56.

Synthesis and Antimicrobial Activity of some new Benzocoumarin Amino Acid Derivative

Catrina: The International Journal of Environmental Sciences
Article 7, Volume 13, Issue 1, 2015, Pages 53-56    PDF (286.06 K)
Document Type: Original Article
Authors
El-Sayed El-Tamany; Ibrahim Ali; Hamdy Soliman; Sally Fouad*
Department of Chemistry, Faculty of Science, Suez Canal University, Ismailia, Egypt
Abstract
A series of new benzocoumarin amino acid derivatives were synthesized with the aim of evaluating their antimicrobial activity. Their chemical structures were confirmed by 1H-NMR and mass spectrometry. The antimicrobial activity was screened on two types of bacteria S. aureus and E. coli besides, two types of fungi Alternari brassicicola and Fusarium oxysporum. Out of the eleven tested compounds, two derivatives benzo [5,6] coumarin-3-carboxylic acid 1 and Benzo [5,6] coumarine-3-carboxyl DL- threonine methyl ester 4c exhibited good activity at 1000 ppm against Gram-positive bacteria S. aureus especially compound 1 which has an activity greater than that of the reference drug (Gentamicin ®).
Keywords
Amino acids; Antibacterial activity; Benzocoumarin
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