COMPARATIVE STUDY ON INCLUSION COMPLEXATION OF HEPTAKIS (2,6-di-O-METHYL)-β- CYCLODEXTRIN, β-CYCLODEXTRIN AND ɣ-CYCLODEXTRIN WITH KETOCONAZOLE IN AQUEOUS SOLUTION AND SOLID STATE. | ||
| Zagazig Journal of Pharmaceutical Sciences | ||
| Article 11, Volume 7, Issue 1, June 1998, Pages 87-93 PDF (4.37 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/zjps.1998.184817 | ||
| Authors | ||
| Mohamed M EL-Sayed* 1; Ahmed Bosela2 | ||
| 1Dept. of Pharmaceutics, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt. | ||
| 2Dept. of Pharmaceutics, Faculty of Pharmacy, Zagazig University, Egypt. | ||
| Abstract | ||
| The interaction of Ketoconazole with three kinds of cyclodextrins, β-, ɣ- and dimethyl β-cyclodextrin in aqueous solution and solid state was investigated to improve solubility and dissolution rate of the drug. For β- and dimethyl-ß-cyclodextrin, drug solubility increased linearly as a function of cyclodextrin concentration and the solubility curve could be classified as Higuchi AL type which indicated the formation of soluble complexes. Complexation with y-cyclodextrin, however, yielded a Bs type solubility curve. The solid cormplexes in all cases were obtained in a molar ratio of 1:1. The inclusion complexes of the drug with the three Cyclodextrins were investigated using DSC and powder X-ray diffractometry and their dissolution behaviour were examined The dissolution rate of Ketoconazole-dimethyl-β-cyclodextrin complex was significantly faster than other complexes due to its high aqueous solubility and amorphous structure. It was concluded that cyclodextrins may be used to enhance the solubility and dissolution rate of Ketoconazole in water. | ||
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