Effect of ACE inhibitors on Creatinine Clearance and albuminuria in diabetic nephropathy | ||
| The Egyptian Journal of Hospital Medicine | ||
| Article 2, Volume 3, Issue 1, April 2001, Pages 14-20 PDF (271.03 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejhm.2001.18889 | ||
| Author | ||
| Mona Hosny Abdel-Salam | ||
| Internal Medicine Department Ain Shams University | ||
| Abstract | ||
| 30 diabetic female patients were studied for the effect of Ramipril on creatinine clearance and albuminuria, they all were type 2 diabetes mellitus and were on oral hypoglycemic drugs. They all had variable degrees of hypertenison. Ramipril was taken for 3 months in a variable doses between 5 and 10 mg/day. Creatinine clearance and albuminuria were determined before and after treatment. Patients were divided into 3 groups: Group 1: 10 patients with albuminuria and mild hypertension. Group 2: 10 patients with albuminuria and moderate hypertension. Group 3: 10 patients with macroalbuminuria and moderate to severe hypertension. In our study, Group 1 has made maximum benefit of Ramipril as regards highly significant decrease (P= .002) of creatinine clearance and of albuminuria which improved significantly (P=.001). Group 2 had a lesser success with only decrease of albuminuria significantly (P=.005) but with insignificant decrease of level of creatinine clearance. Group 3 with macroalbuminuria did not benefit from Ramipril effect on albuminuria but there was a significant decrease in creatinine clearance below normal levels (P=.001). Conclusion: Early and tight control of blood pressure by Ramipril is needed to achieve a success in treating diabetic nephropathy with microalbuminuria. In our study, patients with macroalbuminuria did not benefit from Ramipril treatment. | ||
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