Evaluation of Biochemical Bone Markers in Children with Nephrotic Syndrome with Correlation to Its Severity | ||
| The Egyptian Journal of Hospital Medicine | ||
| Article 14, Volume 85, Issue 1, October 2021, Pages 2751-2757 PDF (385.71 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejhm.2021.189850 | ||
| Authors | ||
| Mansour Khamees Faraj; Samar Mahmoud Abd Elhalim; Dina Mohamed Shokry; Sahbaa Fehr Mohamed Hafez | ||
| Abstract | ||
| Background: Vitamin D is a vital component of bone metabolism and calcium homeostasis, and its deficiency is known to cause rickets, osteomalacia and hypocalcemia. Objective: The aim of this study was to evaluate vitamin D level in patients with nephrotic syndrome and its relation to calcium. Patients and methods: This study was a case-control study carried out at Pediatric Nephrology Unit Pediatric Department, Faculty of Medicine, Zagazig University Hospitals from June 2020 to December 2020. It included 108 patients divided into 2 groups; each group included 54 patients.1st group was patients with nephrotic syndrome and 2nd group was healthy children as control group. A detailed history and clinical examination including anthropometry was taken for cases of Nephrotic syndrome admitted to the hospital. The patients underwent the following investigations: serum albumin, serum cholesterol, C3, C4, alkaline phosphatase, total calcium, ionized calcium, 25(OH) vitamin D, CBC, renal function test, urine analysis urine albumin/creatinine ratio, 24hr urine protein and X-ray bone. Results: There was statistically significant relation between vitamin D level and steroid response where steroid-resistant patient had lower vitamin level followed by steroid-dependent then steroid-sensitive patients. There was non-significant correlation between vitamin D and occurrence of relapse. Conclusion: Vitamin D and calcium supplementation should be considered in nephrotic patients. | ||
| Keywords | ||
| Nephrotic syndrome (NS); Vitamin D; Biochemical bone markers | ||
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