El Ghaiaty, H., Abdel.Haie, O., Hosny, M., Dabour, A. (2018). Single Voxel Spectroscopy Findings in Epileptic Children with Negative Conventional Magnetic Resonance Imaging of the Brain. test, 3(2), 15-21. doi: 10.21608/bjas.2018.191152
H.A. El Ghaiaty; O.M. Abdel.Haie; M.M. Hosny; A.S. Dabour. "Single Voxel Spectroscopy Findings in Epileptic Children with Negative Conventional Magnetic Resonance Imaging of the Brain". test, 3, 2, 2018, 15-21. doi: 10.21608/bjas.2018.191152
El Ghaiaty, H., Abdel.Haie, O., Hosny, M., Dabour, A. (2018). 'Single Voxel Spectroscopy Findings in Epileptic Children with Negative Conventional Magnetic Resonance Imaging of the Brain', test, 3(2), pp. 15-21. doi: 10.21608/bjas.2018.191152
El Ghaiaty, H., Abdel.Haie, O., Hosny, M., Dabour, A. Single Voxel Spectroscopy Findings in Epileptic Children with Negative Conventional Magnetic Resonance Imaging of the Brain. test, 2018; 3(2): 15-21. doi: 10.21608/bjas.2018.191152

Single Voxel Spectroscopy Findings in Epileptic Children with Negative Conventional Magnetic Resonance Imaging of the Brain

Benha Journal of Applied Sciences
Article 4, Volume 3, Issue 2, July 2018, Pages 15-21    PDF (340.24 K)
Document Type: Original Research Papers
DOI: 10.21608/bjas.2018.191152
Authors
H.A. El Ghaiaty1; O.M. Abdel.Haie2; M.M. Hosny1; A.S. Dabour1
1Pediatrics Dept, Faculty of Medicine, Benha Univ, Benha, Egypt
2Radiology Dept, Faculty of Medicine, Benha Univ, Benha, Egypt
Abstract
MRI plays a key role in the evaluation of pediatric patients with seizures and is considered important for the detection of epileptogenic lesions. However, MRS is not as widely used for the evaluation of children with seizures and is not included in the guidelines of the ILAE for the evaluation of infants and children with many types of epilepsy in 2009
Evaluate the Diagnostic and prognostic role of Magnetic Resonance Spectroscopy in the evaluation of non-lesional epilepsy in pediatric patients
Our study was a prospective controlled study. It had been held up on pediatric epileptic patients who were regularly following in the pediatric neurology clinic over one year from July 2017 to July 2018.It included two groups: the case group that included 50 epileptic children with normal conventional MRI brain study and the control group that included 20 non epileptic children.
there was statistical significant differences between  patients with intractable seizures and those with non-intractable seizures regarding   NAA/Cr ratio  in basal ganglia, white matter, Also there were statistical significant difference between  patients with intractable seizures and those with non- intractable seizures regarding   NAA/Cr+Cho ratio  in basal ganglia. A ratio of NAA/Cr in basal ganglia with best cut off value ≤ 1.5 could differentiate epileptic children who will respond to treatment from those with intractable seizures with sensitivity of 100%and specificity of 62%. Also, a ratio of NAA/Cr in white matter with best cut off value ≤ 1.9 mg/dl could differentiate epileptic children who will respond to treatment from those with intractable seizures with sensitivity of 100% and specificity of 65%.
MRS spectroscopy can be used as a prognostic tool to predict epileptic children who will develop intractable epilepsy
 
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