CD44 and p53 co-expression in high grade, muscle invasive bladder urothelial carcinoma with and without schistosomiasis | ||
| Egyptian Journal of Cancer and Biomedical Research | ||
| Article 7, Volume 5, Issue 3, September 2021, Pages 69-75 PDF (4.64 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/jcbr.2021.39890.1064 | ||
| Authors | ||
| Rehab Sharaf El Deen* 1; Osama Sayed2; Wesam Moustafa3 | ||
| 1Pathology Department, Faculty of Medicine, Beni Suef University, Beni Suef, Egypt | ||
| 2Urology Department, Faculty of Medicine, Beni Suef University, Beni Suef, Egypt | ||
| 31Pathology Department, Faculty of Medicine, Beni Suef University, Beni Suef, Egypt | ||
| Abstract | ||
| Background & Objectives: In Egypt, most patients diagnosed as urothelial carcinoma (UC) have high grade and muscle-invasive tumors that are commonly associated with schistosomal cystitis. CD44 and p53 may represent potential targets for anticancer treatment. We aimed to assess the expression of CD44 & p53 and to determine their association in high grade, muscle-invasive tumors. Materials and Methods: Thirty four cystectomy cases with high-grade muscle-invasive UC were collected. Sections were stained for CD44 and p53 taking 10% and 20% positivity as cutoff values, respectively. Results: Median age was 60.5 years. Male/female ratio was 4:1.Fourteen cases were T2, 12 were T3, and 8 were T4. Nodal metastasis was evident in 8 cases. Conventional histology was seen in 38%, followed by squamous differentiation in 24%. Twenty patients had bilharzial cystitis. CD44 was positive in 8.8% of cases whereas p53 immunopositivity was noted in 76.5%. CD44 and p53 expression had no statistical association with stage (p < /em>=0.52 and 0.97) or bilharzial infestation (p=0.34 and 0.16). There was no significant association between CD44 expression and that of p53, p= 0.06. Conclusion: High-grade muscle-invasive Schistosomal associated urothelial carcinomas are common, but with limited CD44 and p53 co-expression. | ||
| Keywords | ||
| Muscle invasive; urothelial carcinoma; p53; CD44; high grade | ||
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