hussien, M., samy, A., Rizk, A., EL-Henawey, M., Karrouf, G. (2022). Potential effect of Platelet Rich Fibrin and Chitosan on healing of surgically induced lacerated superficial digital flexor tendon in donkeys. test, (), -.
mahmoud hussien; alaa samy; Awad Rizk; Mohamed EL-Henawey; Gamal Karrouf. "Potential effect of Platelet Rich Fibrin and Chitosan on healing of surgically induced lacerated superficial digital flexor tendon in donkeys". test, , , 2022, -.
hussien, M., samy, A., Rizk, A., EL-Henawey, M., Karrouf, G. (2022). 'Potential effect of Platelet Rich Fibrin and Chitosan on healing of surgically induced lacerated superficial digital flexor tendon in donkeys', test, (), pp. -.
hussien, M., samy, A., Rizk, A., EL-Henawey, M., Karrouf, G. Potential effect of Platelet Rich Fibrin and Chitosan on healing of surgically induced lacerated superficial digital flexor tendon in donkeys. test, 2022; (): -.

Potential effect of Platelet Rich Fibrin and Chitosan on healing of surgically induced lacerated superficial digital flexor tendon in donkeys

Mansoura Veterinary Medical Journal
Articles in Press, Accepted Manuscript, Available Online from 03 October 2022
Document Type: Original Articles
Authors
mahmoud hussien* 1; alaa samy2; Awad Rizk3; Mohamed EL-Henawey4; Gamal Karrouf2
1surgery, anesthesiology and radiology department, faculty of veterinary medicine, Mansoura university, Mansoura, Egypt
2Department of Surgery, Anesthesiology and Radiology, Faculty of Veterinary Medicine , Mansoura University, Mansoura 35516, Egypt
3Surgery department, Veterinary medicine faculty, mansoura university
4Physics department, faculty of science, Mansoura university, Egypt
Abstract
Objective: To investigate the effects of platelet-rich fibrin (PRF) and chitosan (Ch) on the healing of superficial flexor tendon defects in a donkey model.
Design: A randomized experimental study.
Animals: Eighteen clinically healthy male donkeys aged 24.5± 3.4 months old and weighing 126.5 ± 12.1 kg body weight (BW). A full thickness defect of the superficial flexor tendon (SDFT) was performed at the mid metatarsus, tenorrhaphy was performed using bunnel suture pattern leaving a 1cm defect. These animals were allocated into three groups (6 animals/each). Group I (control group): no biomaterials were added; Group II (PRF group): the SDFT gap was filled with autogenous PRF; Group III (PRF/Ch group): a combination of autogenous PRF and chitosan were used to fill the SDFT gap. Ultrasonographic examinations was carried out at 1, 2 and 3 months postoperatively, imaging characteristics were compared at each time point.
Results: In PRF and PRF/Ch groups showed significant (P>0.00) improvement of the tendon echogenicity, fiber alignment and thickness compared to control group. In PRF and PRF/Ch treated groups, SDFT showed a well-formed and oriented tendon fiber with normal thickness and normal crescent shape.
Conclusion and clinical relevance: on the bases of the tendon echogenicity, fiber alignment, shape, position, and thickness, PRF and chitosan can improve tendon healing and could provide a new bioscaffold-based strategy for SDFT regeneration in donkeys.
Keywords
Platelet Rich Fibrin; superficial flexor tendon; Chitosan
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