The Predictive Value of Vanin-1 in Pediatric Immune Thrombocytopenia | ||
| The Egyptian Journal of Hospital Medicine | ||
| Article 47, Volume 85, Issue 2, October 2021, Pages 3737-3741 PDF (710.98 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejhm.2021.203758 | ||
| Authors | ||
| Mohamed Eissa* ; Amal Zidan; Alaa A. Omran | ||
| KSA, Abha, 61412, P.O. Box 641 | ||
| Abstract | ||
| Background: Immune thrombocytopenia (ITP) has oxidative stress-related pathway as one of its possible mechanisms. Vanin-1 (VNN1) is an oxidative stress sensitive sensor. Objective: The present study was conducted to assess the clinical significance of VNN1 in pediatric ITP patients. Patients and Methods: A total of 50 kids with ITP have been involved in this work; 25 newly diagnosed, 25 chronic patients with ITP more than 12 months (15 responders and 10 non responders to treatment) and 25 apparently healthy children. All groups had their serum VNN-1 levels checked using a two-antibody sandwich enzyme-linked immunosorbent test. Results: The serum VNN1 level was significantly higher in ITP group than control group (p˂0.001). The level of serum VNN1 was significantly very high in newly diagnosed ITP group (p˂0.001) in comparison to chronic responders and chronic non responders ITP groups. Moreover, there was a significant increase in serum VNN1 level in chronic non responders ITP group (p˂0.001) compared to chronic responders group. In newly diagnosed ITP group, both age (r=-0.62, p=0.006) and the platelet count (r=-0.46, p=0.01) had a significant negative connection with serum VNN1 level. A cut-off value lower than 0.6 ng/ml for serum VNN1 could be used to distinguish the chronic non-responders ITP from chronic responders patients with 100 percent specificity and 90 percent sensitivity. Conclusion: From our current results, it is hypothesized that high VNN1 level plays a role in the pathogenesis and progress of pediatric ITP. | ||
| Keywords | ||
| Oxidative stress; Pathogenesis; Pediatric ITP; Responders; Vanin-1 | ||
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