Quercetin attenuates testicular dysfunction induced by aluminum chloride in male Wistar rats | ||
| Egyptian Journal of Chemistry | ||
| Article 57, Volume 65, Issue 6, June 2022, Pages 665-676 PDF (578.37 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejchem.2021.102711.4760 | ||
| Authors | ||
| Asmaa Ahmed Mahmoud* 1; Asmaa M Elfiky2; Hala Ali Elreedy2; Khadiga Salaheldin3 | ||
| 1Department of Zoology, Faculty of Science, Ain Shams University, Cairo, Egypt | ||
| 2Environmental and Occupational Medicine Department, Environmental Research Division, National Research Centre, Cairo, Egypt | ||
| 3National Research Centre, Egypt | ||
| Abstract | ||
| Aluminum (Al) exposure is one of the environmental factors involved in the pathogenesis of male infertility as a global health problem. Quercetin (Q) is a naturally occurring flavonol that improved testosterone (T) level and spermatogenesis against heavy metals-, diabetes-, and cancer-induced testicular intoxication in male rats. The present study aimed to investigate the therapeutic potential of Q against aluminum chloride (AlCl3)–induced testicular dysfunction in rats through evaluation of hormones of the pituitary-testicular axis, sperm parameters in the epididymis, and histological alterations in rat testis. After induction of testicular dysfunction in male rats by oral administration of AlCl3 (50 mg/kg) for 28 days, the therapeutic Q dose (50 mg/kg) was orally administered to rats for 28 days. The rats were divided into four groups (each group comprising eight rats): Normal control (NC), Q, AlCl3, and Q+ AlCl3. Q administration increased final body weight and genital organs’ relative weight, and serum free testosterone (T), luteinizing hormone (LH), and follicle-stimulating hormone (FSH) in the AlCl3-treated rats. Also, Q increased sperm count, motility, and progressive motility in the epididymis in AlCl3-treated rats. Further, Q administration to AlCl3-treated rats caused regeneration of the germinal epithelium in the seminiferous tubules and increased spermatocytes within the lumen. The current study suggests that Q administration may provide a significant therapeutic effect against AlCl3-induced testicular dysfunction in rats via improving the pituitary-testicular axis hormones, leading to increased sperm count and motility in the epididymis; and amelioration of histological alterations observed in the testes of AlCl3-rats. | ||
| Keywords | ||
| Male infertility; Testicular dysfunction; AlCl3; Quercetin | ||
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