Effect of Simvastatin on Alcohol Induced Hepatitis in Experimental Rat | ||
| Advances in Environmental and Life Sciences | ||
| Article 5, Volume 1, Issue 1, January 2022, Pages 48-52 PDF (799.79 K) | ||
| Document Type: Original research articles | ||
| DOI: 10.21608/aels.2022.114518.1004 | ||
| Authors | ||
| Sameh Ahmed Abd elraouf* 1; Amal mohammed Imam1, 2; Wafaa Mohammed Ibrahim3 | ||
| 1Chemistry Department, Faculty of Science, Suez Canal University, 41522 Ismailia, Egypt. | ||
| 2Department of Chemistry, Faculty of Science and Arts, Qurayyat, Jouf University, KSA | ||
| 3Medical Biochemistry Department, Faculty of Medicine, Tanta University, Egypt | ||
| Abstract | ||
| Alcohol drinking are important health concerns worldwide and one of the risk factors for the development of liver disease. There are no FDA-approved medications to prevent or to treat any stage of alcohol-induced liver disease (ALD). Therefore, the therapeutic strategies remain a critical need for those patients. The current study was designed to assess the effect of simvastatin in ethanol induced hepatitis and its progression. We demonstrated that chronic drinking of ethanol significantly elevated liver enzymes which were decrease upon simvastatin treatment, indicating its ameliorative effect. TG level was increased in alcohol induced hepatitis and simvastatin control groups when compared to normal control group and supplementation with simvastatin showed insignificant decrease of serum TG. However, there is insignificant change in the serum total cholesterol in the present model of alcohol induced hepatitis and the present findings represent the reversal of hypercholesteremia after 55 days., these results suggest simvastatin could prove beneficial in the prevention or treatment of ALD. | ||
| Keywords | ||
| simvastatin; Alcohol-induced hepatitis; hypercholesterolemia; Ameliorative effect | ||
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