Preconception H pylori infection might be a risk factor for Development of Early-onset Preeclampsia | ||
| The Egyptian Journal of Fertility and Sterility | ||
| Article 1, Volume 26, Issue 1 - Serial Number 11106352, January 2022, Pages 2-11 PDF (2.51 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/egyfs.2022.216260 | ||
| Author | ||
| Amr Sharaf Elden, Yasmin Mohammed Marei1, 2 | ||
| 1Department of Obstetrics & Gynecology, Faculty of Medicine, Benha University | ||
| 2Department of Medical Biochemistry, Faculty of Medicine, Benha University | ||
| Abstract | ||
| Objectives: Estimation of serum levels of Tumor necrosis factor-α (TNF-α), interleukin-1β and -6 at booking time and at time of diagnosis of preeclampsia (PE) in women infected and un-infected by H pylori (HP). Patients & Methods: 232 primigravida gave blood samples for ELISA determination of HP IgG positivity and were categorized as HP+ and HP- groups. At booking time, systolic (SBP) and diastolic (DBP) blood pressure measures were recorded and serum levels of TNF-α, IL-1β and IL-6 were ELISA estimated (S1 sample). During the 4-weekly visit, BP was recorded to diagnose PE according to the American Society of Hypertension. At time of PE diagnosis, S2 blood sample was obtained for re-estimation of studied cytokines. Results: There were 108 HP+ women and 54 women developed PE; 33 HP+ and 21 HP- women. The incidence of early-onset PE was significantly higher, while the incidence of severe PE was non-significantly higher among HP+ women. Positivity for HP IgG showed positive significant correlation with development of early and severe PE. At booking serum levels of studied cytokines were significantly higher in PE than Non-PE women and in HP+ women than in HP- women and showed positive significant correlation with BP measures at time of diagnosis of PE. Automatic Linear Modeling analysis defined high at booking serum TNF-α as the most important predictor for PE. Conclusion: PE has a higher incidence among women had HP infection, which might be considered as precipitating factor for PE development. The positive correlation between severity of PE, HP-IgG positivity and increased serum levels of inflammatory cytokines represent a dangerous circle entrapping the pregnant women. | ||
| Keywords | ||
| H pylori infection; Preeclampsia; Primigravida; Inflammatory cytokines | ||
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