AMELIORATIVE EFFECT OF THE AQUEOUS EXTRACT OF MUSHROOM (PLEUROTUS OSTREATUS) ON NEUROTOXICITY INDUCED BY CIPROFLOXACIN IN RATS | ||
| Assiut University Journal of Multidisciplinary Scientific Research | ||
| Volume 50, Issue 1, June 2021, Pages 1-22 PDF (1.18 M) | ||
| Document Type: Novel Research Articles | ||
| DOI: 10.21608/aunj.2021.219958 | ||
| Abstract | ||
| Ciprofloxacin (CPX) is a broad-spectrum antibiotic widely used in both human and veterinary medicine, however, it is misuse causes neurological disorders. In the current study, the protective effects of Mushroom P. ostreatus aqueous extract (MAE) against CPX-induced neurotoxicity have been investigated. Twenty -four adult rats were allocated into four groups, control group, CPX group that received a daily dose of 50 mg/kg for two weeks, MAE group that was supplemented with a daily dose of 200 mg/kg for two weeks and CPX plus MAE group which received CPX (50 mg/kg) for two weeks then supplemented with MAE (200mg/kg) for another two weeks. The results showed that CPX caused alterations in the levels of acetylcholinesterase (AChE), glutathione (GSH) and lipid peroxidation in the brain tissue accompanied with neurodegenertion in the cerebral cortex and hippocampus in comparison with the control. However, MAE caused alterations in the levels of AChE, total antioxidant capacity and LPO in comparison with CPX group. Brain of rats treated with CPX and supplemented with MAE showed improvement in the parameters of oxidative stress and the histological structure with less neurodegenerative cells in the cerebral cortex and hippocampus. In conclusion, CPX caused neurotoxicity mediated by oxidative stress and MAE can ameliorate brain tissue against CPX- induced brain toxicity due to its content of antioxidant compound. | ||
| Keywords | ||
| Ciprofloxacin; brain; rats; oxidative stress; Mushroom aqueous extract | ||
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