Said, M., Ibrahim, R., Allam, M. (2022). Effect of tumor necrosis factor alpha inhibition with etanercept on renal functions in L-NAME induced hypertensive rats: insights into the possible mechanisms. test, 42(2), 163-179. doi: 10.21608/besps.2021.93323.1111
Mona AbdelAzim Said; Reham Mohammed Ibrahim; Mona Maher Allam. "Effect of tumor necrosis factor alpha inhibition with etanercept on renal functions in L-NAME induced hypertensive rats: insights into the possible mechanisms". test, 42, 2, 2022, 163-179. doi: 10.21608/besps.2021.93323.1111
Said, M., Ibrahim, R., Allam, M. (2022). 'Effect of tumor necrosis factor alpha inhibition with etanercept on renal functions in L-NAME induced hypertensive rats: insights into the possible mechanisms', test, 42(2), pp. 163-179. doi: 10.21608/besps.2021.93323.1111
Said, M., Ibrahim, R., Allam, M. Effect of tumor necrosis factor alpha inhibition with etanercept on renal functions in L-NAME induced hypertensive rats: insights into the possible mechanisms. test, 2022; 42(2): 163-179. doi: 10.21608/besps.2021.93323.1111

Effect of tumor necrosis factor alpha inhibition with etanercept on renal functions in L-NAME induced hypertensive rats: insights into the possible mechanisms

Bulletin of Egyptian Society for Physiological Sciences
Article 3, Volume 42, Issue 2, April 2022, Pages 163-179    PDF (779.43 K)
Document Type: Original Article
DOI: 10.21608/besps.2021.93323.1111
Authors
Mona AbdelAzim Said* 1; Reham Mohammed Ibrahim2; Mona Maher Allam2
1Physiology department, faculty of Medicine, Benha University, Egypt.
2Physiology department, Faculty of Medicine, Benha University, Egypt
Abstract
Many studies suggest the dominant role of the inflammatory cytokine, tumor necrosis factor alpha (TNF-α) in the prognosis of hypertension and end stage renal disease (ESRD). The objective of this study was to investigate the effects of TNF-α inhibition on renal functions in Nω-nitro-L-arginine methyl ester (L-NAME) induced hypertensive rats and the potential underlying mechanisms. Four groups of rats were used in the study for 3 weeks period; normal control group, TNF- α inhibitor (etanercept) group, L-NAME-induced hypertensive group and L-NAME + etanercept group. L-NAME group showed elevated systolic and diastolic blood pressure, plasma urea, creatinine, plasma renin activity, angiotensin II, kidney tissue nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, TNF- α and malondialdehyde (MDA) together with decreased creatinine clearance rate and renal antioxidants. Treatment with etanercept affords antihypertensive effect and ameliorates L-NAME induced renal impairment by improving renin–angiotensin system (RAS) and NADPH oxidase as well as by attenuating oxidative stress.
Keywords
TNF-α; Etanercept; Hypertension; Renin – angiotensin system; Oxidative stress
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