Ilias, B., Sofiane, B., Hicham, M., Abdel El Hamid, D., Djamel, B., Kheira, R., Hadjer, B., Slimane, B., Abbassia, D. (2022). Protective Effects of Apricot Oil Against Mercuric Chloride-Induced Hepato-Renal Toxicity in Rats. test, 14(1), 137-147. doi: 10.21608/eajbsd.2022.234198
Bensaid Ilias; Bouazza Sofiane; Maï Hicham; Djebbar Ahmed Abdel El Hamid; Benguerrache Djamel; Rebbah Kheira; Bekhadda Hadjer; Brikhou Slimane; Demmouche Abbassia. "Protective Effects of Apricot Oil Against Mercuric Chloride-Induced Hepato-Renal Toxicity in Rats". test, 14, 1, 2022, 137-147. doi: 10.21608/eajbsd.2022.234198
Ilias, B., Sofiane, B., Hicham, M., Abdel El Hamid, D., Djamel, B., Kheira, R., Hadjer, B., Slimane, B., Abbassia, D. (2022). 'Protective Effects of Apricot Oil Against Mercuric Chloride-Induced Hepato-Renal Toxicity in Rats', test, 14(1), pp. 137-147. doi: 10.21608/eajbsd.2022.234198
Ilias, B., Sofiane, B., Hicham, M., Abdel El Hamid, D., Djamel, B., Kheira, R., Hadjer, B., Slimane, B., Abbassia, D. Protective Effects of Apricot Oil Against Mercuric Chloride-Induced Hepato-Renal Toxicity in Rats. test, 2022; 14(1): 137-147. doi: 10.21608/eajbsd.2022.234198

Protective Effects of Apricot Oil Against Mercuric Chloride-Induced Hepato-Renal Toxicity in Rats

Egyptian Academic Journal of Biological Sciences, D. Histology & Histochemistry
Article 9, Volume 14, Issue 1, June 2022, Pages 137-147    PDF (1.07 M)
Document Type: Original Article
DOI: 10.21608/eajbsd.2022.234198
Authors
Bensaid Ilias1; Bouazza Sofiane1; Maï Hicham1; Djebbar Ahmed Abdel El Hamid1; Benguerrache Djamel1; Rebbah Kheira1; Bekhadda Hadjer1; Brikhou Slimane1; Demmouche Abbassia2
1Biotoxicology laboratory. Department of Biology, Faculty of Natural Sciences and life-Djillali Liabes University of Sidi Bel Abbes, Algeria
2Biotoxicology laboratory. Department of Biology, Faculty of Natural Sciences and life-Djillali Liabes University of Sidi Bel Abbes, Algeria
Abstract
This study was designed to investigate the possible protective role of apricot oil against liver and renal toxicity induced by mercuric chloride in rats by using biochemical approaches and tissue analysis. Twenty-four adult male albinos Wistar rats were randomly divided into four groups, the first served as a control; whereas the remaining groups were respectively treated with:  mercuric chloride (0.25 mg/kg body weight i.p) + apricot oil (5ml/ kg b.w; by gavage after one month); apricot oil (5ml/ kg b.w; by gavage) and combination of apricot oil and HgCl2 at the same time. The result showed a moderately decreased body weight in all treated groups compared with the control (p = 0,017). Exposure of rats to mercuric chloride caused a significantly decreased activity of AST, ALT compared with the control, the differences were statistically significant for the AST (P=0,017) and ALT (P=0,027). Supplementation of apricot oil resulted in a decreased level of AST antioxidant enzymes level in the liver. Pancreatic hypoglycemia was noted in the group treated with mercuric chloride plus apricot oil compared to the control. Apricot oil also produced substantial decreases in the concentrations of total cholesterol, urea and creatinine (P<0,05). A significant decrease in phosphorus levels in the mercuric chloride group compared to control was observed. Supplementation of apricot oil resulted in a decrease in protide levels. The results clearly demonstrate that apricot oil treatment augments the antioxidants defense mechanism in mercuric chloride-induced toxicity and provides evidence that it may have a therapeutic role in free radical-mediated diseases.
Keywords
Mercury chloride; Apricot oil; Antioxidant; Health; Wistar rats
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