STUDY OF THE RELATION BETWEEN LONG NON-CODING RIBONUCLEIC ACID SNHG16 AND VITAMIN D STATUS IN JUVENILE MYOCLONIC EPILEPSY EGYPTIAN PATIENTS | ||
| ALEXMED ePosters | ||
| Article 1, Volume 4, Issue 2, June 2022, Pages 15-16 | ||
| Document Type: Preliminary preprint short reports of original research | ||
| DOI: 10.21608/alexpo.2022.139317.1406 | ||
| Authors | ||
| Ayman Abdo Barghash1; Eman Soliman Kamha1; Hala Elsayed Rashad1; hany Mohammed El Deeb2; Salma Sabry Gomaa Moustafa* 1 | ||
| 1Department of Medical Biochemistry, Faculty of Medicine, University of Alexandria | ||
| 2Department of Neuropsychiatry, Faculty of Medicine, University of Alexandria | ||
| Abstract | ||
| Epilepsy is a neurological disease characterized by recurring unprovoked seizures which seriously affect daily activities, physical and mental health of epileptic patients. Epilepsy affects people of all ages, races, social classes. Despite considerable progress in clinical and preclinical epilepsy research, the pathophysiology of epilepsy remains an open question. LncRNAs are a heterogeneous group of non-coding RNA molecules that can perform a wide range of molecular and cellular functions by employing various modes of action. LncRNAs regulate the expression of pro-inflammatory and anti-inflammatory cytokines in the CNS. SNHG16 is a newly identified oncogene that has been shown to regulate certain inflammatory pathways. Several studies suggest that vitamin D3 raises the threshold of chemically induced seizures and suppresses epileptic activity by reducing the expression of certain proconvulsant cytokines in addition to its anti-inflammatory role in the CNS. Aim of the work The aim of the present work was to study the relation between lncRNA SNHG16 and vitamin D3 status in juvenile myoclonic epilepsy Egyptian patients. | ||
| Keywords | ||
| SNHG16; VITAMIN D; JUVENILE MYOCLONIC EPILEPSY | ||
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