The Role of Platelets Rich Plasma (PRP) in Recurrent Implantation Failure (RIF) | ||
| Benha Journal of Applied Sciences | ||
| Article 19, Volume 7, Issue 5, May 2022, Pages 127-134 PDF (457.59 K) | ||
| Document Type: Original Research Papers | ||
| DOI: 10.21608/bjas.2022.244603 | ||
| Authors | ||
| M.A. Elnafarawi; M.F. Elsherbiny; W.M. Tawfik; D.M. EIbrahim | ||
| Obstetrics and Gynecology, Dept., Faculty of Medicine, Benha Univ., Benha, Egypt | ||
| Abstract | ||
| Infertility therapy has been advocated using a variety of ways. The implantation of many embryos is still a problem, despite the presence of a variety of assisted reproductive technologies (ART). C-reactive protein, growth factor, prostaglandin and other binding molecules are released by the endometrium when it's receptive to fertilisation. It is critical for embryo implantation if the endometrium be in the proper condition. Repeated implantation failure (RIF) is defined by the European Society of Human Reproduction and Embryology as the absence of a gestational sac in the 5-week old ultrasonography after three different embryo transfers. Autologous blood samples are used to obtain platelet-rich plasma (PRP), which has a concentration of 4–5 times that of circulating blood. ART research aimed at increasing the success rate and reducing the cost of treatment may be beneficial. The purpose of this research was to determine if intrauterine perfusion of autologous platelet-rich plasma (PRP) improves pregnancy rates in patients with RIF. Methods: Study participants were divided into two groups: Group A (PRP group), which comprised 37 women who underwent intrauterine infusion of PRP 48 hours prior to embryo transfer (ET), and Group B (Control group), which included 37 women who did not receive PRP. This study found no significant differences in demographic data or time spent unsuccessfully trying to conceive between the two groups. In terms of AMH levels, the two groups did not vary significantly. When comparing the PRP group to the control group, the AFC was considerably greater in the PRP group. The PRP group had a statistically greater endometrial thickness than the control group after treatment. In comparison to the control group, the PRP group had statistically substantially more recovered oocytes. In comparison to the control group, the PRP group had considerably more MII oocytes. Between the two groups, the number of embryos transplanted was statistically indistinguishable. There was a statistically significant difference in the number of blastocysts formed by PRP compared to the control group. The PRP group had an 81.1 percent rate of normal fertilisation compared to the control group, which was statistically significant (45.9 percent ). Compared to the control group, the PRP group had a clinical pregnancy rate of 48.6 percent, which was statistically significant (18.9 percent ). No statistically significant difference was seen when it came to spontaneous miscarriage rates between the PRP and control groups. To summarise, PRP infusion seems to be a safe and successful treatment for enhancing endometrial receptivity, implantation, and pregnancy, all without causing harm to the patient. Furthermore, PRP is inexpensive and made from your own blood, so there's no need to worry about immune responses or infection transmission. | ||
| Keywords | ||
| Platelets Rich Plasma; PRP; Recurrent Implantation Failure; RIF | ||
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