Clinicobiochemical effects of Phyllanthus niruri and Plantago major on CCl4 Intoxicated rat model | ||
| Suez Canal Veterinary Medical Journal. SCVMJ | ||
| Articles in Press, Accepted Manuscript, Available Online from 23 June 2022 | ||
| Document Type: Original Article | ||
| DOI: 10.21608/scvmj.2022.144002.1084 | ||
| Authors | ||
| Asmaa Khamis1; Osama Abdalla2; Mohamed Hashem3; Noha Sayed Abdelnaeim* 4 | ||
| 1clinical pathology dep. faculty of Veterinary Medicine, Suez Canal University, Egypt | ||
| 2Professor of Clinical Pathology Faculty of Veterinary Medicine, Suez Canal University | ||
| 3Clinical Pathology Department , Faculty of Veterinary Medicine, Zagazig University, Egypt | ||
| 4Clinical Pathology, Faculty of Veterinary Medicine, Suez Canal University, Egypt | ||
| Abstract | ||
| Carbon tetrachloride is a well-known hepatotoxin that is widely used to induce acute toxic liver injury. Phyllanthus niruri (PN) and Plantago major (PM) have hepatoprotective properties.The purpose of our study was to evaluate the protective effects of PN and PM on carbon tetrachloride intoxicated rats. Sixty male albino rats were randomly assigned into six equal groups. The first group was kept as a control and received purified water. The second and third groups were administered PN and PM (500 mg/kg/day) orally for 31 days, respectively. The fourth group was injected intraperitoneally with CCl4 (2 ml/kg/day) on days 15 and 16 of the experiment. The fifth and sixth groups were given PN and PM (500 mg/kg/day) orally for 31 days, respectively, and were injected with CCl4 on days 15 and 16. On days 17 and 32 of the experiment, five rats were assembled randomly from each group, and blood samples were collected for analyzing serum biochemical parameters including liver enzymes, total bilirubin, direct and indirect bilirubin, proteinogram, and lipid profile. Our results revealed a significant increase in ALT, AST, ALP, GGT, total bilirubin, direct and indirect bilirubin, total cholesterol, total triglyceride, LDL, and VLDL and a significant decline in total protein, albumin, and HDL in the CCl4 group. However, PN+CCl4 group significantly improved liver enzymes, bilirubin, albumin, total cholesterol, total triglyceride, LDL, and VLDL. PM+CCl4 group revealed improvement in AST, ALP, total cholesterol, total triglyceride, LDL, and VLDL. Finally, it could be concluded that PN and PM have beneficial effects against CCl4 hepatotoxicity in rats. | ||
| Keywords | ||
| carbon tetrachloride; Phyllanthus niruri; Plantago major; hepatotoxicity; rats | ||
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