Immunohistochemical Expression of SOX2 and EpCAM in Colorectal Cancer and its Precancerous lesions | ||
| Zagazig University Medical Journal | ||
| Article 29, Volume 30, Issue 2, March and April 2024, Pages 522-532 PDF (2.06 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/zumj.2022.145296.2587 | ||
| Authors | ||
| Aziza E. Abdelrahman* 1; Asmaa Abdullatif2 | ||
| 1Pathology department, faculty of medicine, zagazig university, Egypt | ||
| 2pathology department, faculty of medicine, zagazig university | ||
| Abstract | ||
| BACKGROUND: There is an actual need for novel prognostic biomarkers to improve colorectal cancer (CRC) patient’s outcome. OBJECTIVES: To evaluate SOX2 and EpCAM immunohistochemical expression in 40 cases of CRC and premalignant lesions. METHODS: The immunohistochemical expression was done according to Envision polymer technique on 40 cases of CRC besides twenty specimens of premalignant lesions. Furthermore, their clinicopathological significance was statistically investigated. RESULTS: High SOX2 immunoexpression was detected in 57.5 % of CRC cases and was significantly associated with tumor size, high tumor grade, LVI, LN involvement, advanced tumor stage, and tumor budding (P=0.04, P | ||
| Keywords | ||
| colorectal carcinoma; SOX2; EpCAM; prognostic factor | ||
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