Study of uterine artery Doppler velocity waveforms in patients with recurrent early pregnancy loss | ||
| Benha Journal of Applied Sciences | ||
| Article 15, Volume 7, Issue 7, July 2022, Pages 101-106 PDF (578.6 K) | ||
| Document Type: Original Research Papers | ||
| DOI: 10.21608/bjas.2022.253639 | ||
| Authors | ||
| M.M. Gadelrab; A.I. Elmashad; Y.M. Edris; H.E. Abdel raziq | ||
| Obstetrics and Gynecology, Dept., Faculty of Medicine, Benha Univ., Benha, Egypt | ||
| Abstract | ||
| Background: Unexplained Recurrent miscarriage remains a frustrating problem for the clinician and a distressing condition for the affected couple. Recurrent pregnancy loss is defined as three or more successive spontaneous abortion. The incidence of recurrent pregnancy loss is 1-2% in the fertile population. The etiology is often unclear and may be multifactorial, with much controversy regarding diagnosis and treatment. This study aimed to find out any difference in uterine artery pulsitility index (PI) between women with history of recurrent unexplained first trimestric abortion and women without this history. Methods: This study was a case-controlled study which included 100 women attended to outpatient clinic of obstetrics and Gynecology Benha university hospitals to find out any difference in uterine artery pulsitility index (PI) between women with history of recurrent unexplained first trimestric abortion and women without this history. Results: The mean age in all women was 29.74 . in Study group, the mean age was 30.18 ± 4.83 ranged between 21 to 38 years while in Control group the mean age was 28.94 ± 5.771 ranged between 20 to 37 years. There were no statistically significant differences between Study group and control group regarding the mean age. In Study group, the mean BMI was 28.47 ± 4.97 while in Control group the mean BMI was 27.58 ± 3.21. The mean times of previous parity in study group was 2.02 ± 1.023 while it was 2.62 ± 1.338 in control group. There were no statistically significant differences between Study group and control group regarding the mean BMI and parity. There were no statistically significant differences between Study group and control group regarding the mean Serum Progesterone level which was Serum Progesterone ng/ml in study group and was 14.4 ± 2.14 ng/ml in control group.Regarding Pulsatility index (PI) in right uterine artery in Study group and control group there was a statistically significant difference with mean value 2.33 ± 0.49 and 2.72 ± 0.69 respectively which reflected increased resistance to blood flow in the right uterine artery in Study group. Comparing PI of left uterine artery in Study group and control group, revealed a significant difference, this indicated increased blood flow resistance in left uterine artery in Study group. As regards PI of both right and left uterine arteries in Study group and control group a statistically significant difference was found. Also we found a statistically significant difference between Study group and control group regarding RI. Based on ROC, the area under the curve was 0.918 with a standard error of 0.03 (95% CI: 0.86-0.98), which implied that the PI could perfectly predict the occurrence of the adverse outcome among pregnant women. Similarly, the cut-off value for PI was 2.65 at 92% sensitivity and 81% specificity for miscarriage. Conclusion: Transvaginal ultrasonography colour Doppler flowmetry can be used to Assess uterine perfusion through measurement of uterine artery Doppler (PI) is recommended as routine investigation for women with Unexplained Recurrent miscarriage which helps in managements and treatment protocols | ||
| Keywords | ||
| uterine artery Doppler velocity waveforms; recurrent early pregnancy loss | ||
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