Assessment of Serum Vitamin B12 Level in Patients with Acne after Isotretenoin Therapy and its correlation to Adverse Mood Changes | ||
| Benha Journal of Applied Sciences | ||
| Article 14, Volume 7, Issue 4, April 2022, Pages 107-111 PDF (450.34 K) | ||
| Document Type: Original Research Papers | ||
| DOI: 10.21608/bjas.2022.254553 | ||
| Authors | ||
| M.I. Mohammed1; M.M. Mahmoud2; W. Mikhael1; G.M. Abd El Khalik1 | ||
| 1Dermatology, Venerology And Andrology, Dept., Faculty of Medicine, Benha Univ., Benha, Egypt | ||
| 2psychiatry, Dept., Faculty of Medicine, Benha Univ., Benha, Egypt | ||
| Abstract | ||
| Acne is a long-term, debilitating skin condition that mostly affects young people between the ages of 11 and 16, peaking at the age of 16, and lasting into their 20s and 30s. Depression, anxiety, and a lack of enjoyment in life on par with those who suffer from chronically crippling conditions such as asthma, epilepsy, diabetes, and arthritis are all common side effects. Vitamin B12 (cyanocobalamin) has also been linked to acne flare-ups and the emergence of acneiform eruptions, particularly in those with pre-existing conditions. Serum vitamin B12 content in individuals with acne vulgaris was examined in this research to see whether there was a link to probable unfavourable mood changes caused by isotretinoin. Methods: A total of 40 people with moderate to severe acne vulgaris were involved in this investigation. For a period of six months, all patients took oral isotretinoin at a dose of 0.5-2 mg/kg/d. For a complete course, the total cumulative dosage was 120-135 mg/kg. The average age of the participants was 20.8 years. Only 15% of the patients were men, whereas 85% of the patients were women. One-half or more of patients had one or more of the following risk factors: a healthy diet high in sugar, a family history of the disease, or psychological stress. All of the patients evaluated had a problem with their face, with the exception of one. In 5 instances, the back was harmed, but in 65 percent of cases, the course progressed. Thirty-three (72.5 percent) instances were classified as severe, while only eleven (27.5 percent) were classified as light. After using isotretinoin theraby for six months, there was a substantial decrease in blood vitamin B12 concentrations (p = 0.0371). Prior to therapy, 13 patients had little depression, 9 patients had mil d depression, and one patient had strong depression, according to their pretreatment depression levels. Moderate acne differed significantly from severe acne. p = 0.0285), the severity of depression. After therapy, 14 patients had minimum depression, 16 had mild depression, and 4 had significant depression, all according to the degree of depression. Patients who received oral isotretinoin for six months showed a significant change in their level of depression before and after treatment (p = 0.0371). Patients with acne who are taking isotretinoin for acne may benefit from having their vitamin B12 levels checked to see whether they are at increased risk for depression. Acne patients on isotretinoin and suffering from depression may benefit from vitamin B12 supplementation. | ||
| Keywords | ||
| Serum Vitamin B12; Acne; Isotretenoin Therapy | ||
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