Letrozole in poor responders undergoing ICSI: an egyptian experience | ||
| The Egyptian Journal of Fertility and Sterility | ||
| Article 5, Volume 16, Issue 2 - Serial Number 11106352, June 2012, Pages 26-28 PDF (1.12 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/egyfs.2012.257690 | ||
| Author | ||
| Mohamed Ibrahem, Hesham Shalan, Abd El Gawad Elmetwally, Mohamed Elnegeri | ||
| Obstetrics and Gynecology. Mansoura University Hospital. Mansoura, Egypt | ||
| Abstract | ||
| Objective: to compare gonadotropine /antagonist protocol with and without Letrozole for controlled ovarian hyperstimulation for poor responder cases undergoing ICSI. Materials & Methods: A prospective randomized case control study performed in Mansoura Fertility Care unit, Mansoura University hospital. Controlled ovarian hyperstimulation using gonadotropins/antagonist protocol with (group A) and without Letrozole (group B). The primary outcome is to measure duration of stimulation, total dose of gonDGRWURSLQVVHUXP(OHYHODQGHQGRPHWULDOWKLFNQHVVRQGD\RI+&*DGPLQLVWUDWLRQ7KH number and degree of maturation of retrieved oocytes, fertilization rate and number and grade of the developed embryos were evaluated. Secondary outcome includes ongoing pregnancy and take home baby rates. Results: Duration of stimulation was shorter in group A (10.2± 1.5 days) compared to (11.5± 1.9days) in group B, total dose of gonadotropins was lower in group A (2602±433) in contrast to (2752±515IU) in group B, endometrial thickness was thicker in group B PP FRPSDUHGWR PP LQJURXS$EXWQRVLJQL¿FDQWGLIIHUHQFHZDVGHtected between the two groups apart from mean duration of stimulation. Conclusions: Letrozole as an adjuvant to gonadotropins seems to reduce stimulation period and total gonadotropins units used. | ||
| Keywords | ||
| Key wards: Letrozole; poor responders; controlled ovarian hyperstimulation; ICSI cycles | ||
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