Carvone Hypoglycemic and Hypolipidemic effects by regulation of key proteins involved in fatty acid beta-oxidation in alloxan-induced diabetic rats. | ||
| Bulletin of Faculty of Science, Zagazig University | ||
| Article 10, Volume 2022, Issue 3, October 2022, Pages 96-107 PDF (917.68 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/bfszu.2022.145262.1151 | ||
| Authors | ||
| nabila zein* 1; Marwa Mohamed Shehata2; Atef Mohamed Amer3 | ||
| 118/mandoor street /Zagazig/Sharkia | ||
| 2biochemistry,faculty of science,zagazig university | ||
| 3organic Chemistry Division, Chemistry Department, Faculty of Science, Zagazig University | ||
| Abstract | ||
| Background: Essential oils are natural products with various biological characteristics caused by monoterpenes which have a high probability of producing new drugs Carvone, a monoterpenes has hypolipidemic, anti-inflammatory, hypoglycemic and antioxidant effects . Aim. The aim of this research is to show that carvone has medicinal potential in the treatment of diabetes and hyperlipidemia in alloxan-induced diabetic rats, as well as its effect on insulin activity. Material and methods .Four groups of male albino rats were formed, each with eight rats. In Group 1, healthy rats were provided a standard chow diet and were not given any medications. To develop diabetes, the rats in the other three groups were given a single intraperitoneal administration of alloxan (120 mg/kg), followed by a two-week feeding of an atherogenic hypercholesterolemic diet. The diabetic hyperlipidemic control (DHC) group received no treatment, while the other two groups received carvone (50 mg/kg) daily for one month and a combination drug (atorvastatin 10 mg/kg and metformin100 mg/kg) daily for one month, respectively. Results: our findings a reduction in the levels of blood glucose, cholesterol, triglyceride, LDL, fatty acid desaturase -1(FADS-1) , glucose-6-phosphate catalase -1(G6PC-1) and increase in the level of insulin and Acyle-co-A oxidase -1(ACOX-1) upon administration of carvone, Immunohistochemical investigation and results agree with biochemical indicators to some extent. Conclusion: carvone has anti-diabetic and anti-hyperlipidemia properties in diabetic hyperlipidemic rats by controlling essential proteins involved in fatty acid beta-oxidation (ACOX-1) | ||
| Keywords | ||
| Diabetes mellitus; Hyperlipidemia; Fads-1; G6pc-1; Acox-1 | ||
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