Efficacy and safety of platelet lysate mucoadhesive gel in the treatment of patients suffering from an erosive form of oral lichen planus: A randomized placebo-controlled clinical trial | ||
| Egyptian Dental Journal | ||
| Article 6, Volume 68, Issue 4 - Serial Number 3, October 2022, Pages 3261-3272 PDF (1023.82 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/edj.2022.146525.2166 | ||
| Authors | ||
| Rania Shalby* 1; Dalia El Telbany2; Sandy Hassan3 | ||
| 1Lecturer at Oral Medicine, Diagnosis and Periodontology Department, Faculty of Dentistry, Fayoum University, Egypt | ||
| 2Associate professor at Oral Medicine, Diagnosis and Periodontology Department, Faculty of Dentistry, Fayoum and Ahram Canadian Universities, Egypt | ||
| 3Associate professor of Pharmaceutics, Faculty of Pharmacy, Modern University for Technology and Information (MTI), Cairo, Egypt | ||
| Abstract | ||
| Trial design: The study is a randomized clinical placebo-controlled trial in parallel groups 1:1 allocation ratio. Methods: 30 patients with erosive oral lichen planus were randomly assigned to receive either platelet lysate mucoadhesive gel or placebo vehicle gel 3 times per day for 4 weeks. Outcomes: Assessment of outcomes included a visual analog scale (VAS) for pain as a primary outcome, and the secondary outcomes included improvement in the clinical picture according to thongprasom sign score and any side effects of treatment. Results: results had shown a significant reduction of both pain and clinical scores in both groups at 2, 3, and 4 weeks and at 3 months of follow-up and a significant difference in pain and clinical scores between the intervention and control group at each visit as well as at 3 months follow up in which the intervention had greater pain reduction and clinical improvement. Conclusion: Platelet lysate mucoadhesive gel is a promising material for managing erosive OLP and could be considered a suitable, safe, and easy alternative to other hemo-derived products. However, further larger randomized controlled trials are recommended. | ||
| Keywords | ||
| Platelet lysate; Platelet-rich plasma; Platelet-derived growth factors; Oral lichen planus; Erosive oral lichen planus | ||
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