Role of FNDC5 gene polymorphism in patients with diabetic nephropathy | ||
| Sohag Medical Journal | ||
| Volume 26, Issue 3, September 2022, Pages 35-40 PDF (361.65 K) | ||
| DOI: 10.21608/smj.2022.167010.1347 | ||
| Authors | ||
| samar mostafa ;Moahamed Kamel* 1; Nagwa sayed Ahmed2; Muhammed Ahmed Abd El Moety3; Nayel Abdelhameed Zaki4 | ||
| 1Department of Medical Biochemistry, Faculty of Medicine, Sohag University | ||
| 2Department of Medical Biochemistry Department Faculty of Medicine Sohag University | ||
| 3Department of Medical Biochemistry Faculty of Medicine Sohag University | ||
| 4Internal medicine departement sohag university hospital.sohag.egypt | ||
| Abstract | ||
| A category of metabolic illnesses known as diabetes mellitus (DM) is characterized by levels of hyperglycemia that persist for an extended length of time. The primary underlying cause of Type 2 diabetes mellitus (DM) is insulin resistance, which may also be accompanied by substantially decreased insulin production. The long-term presence of hyperglycemia causes several problems, including diabetic nephropathy. White adipose tissue (WAT) and brown adipose tissue (BAT) are the two separate compartments that make up adipose tissue. BAT has a thermogenic activity and controls body temperature by dissipating energy through heat generation. It is believed that the browning of adipose tissue will increase insulin sensitivity and lessen weight gain. Muscle-adipose tissue cross-talk may be facilitated by irisin, a newly identified exercise-mediated myokine that controls energy metabolism by transforming white into brown fat. When the precursor plasma membrane protein fibronectin type III domain-containing protein 5 (FNDC5) is broken down, irisin is created and released into the bloodstream. In individuals with diabetic nephropathy and chronic kidney disease (CKD), irisin was discovered to be related to renal functioning. To identify variations in the incidence of diabetic nephropathy among diabetic patients, the role of FDNC5 genetic polymorphism and irisin expression in T2DM nephropathy is being studied | ||
| Keywords | ||
| FNDC5; Gene polymorphism; Diabetic nephropathy; Irisin; type 2 diabetes mellitus | ||
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