Management of Muscle Invasive Bladder Cancer with Weekly Gemcitabine Concurrent with Radiotherapy Post-Transurethral Tumor Resection in Old Fragile Patients: our Institute Experience | ||
| Zagazig University Medical Journal | ||
| Article 14, Volume 30, Issue 1, January and February 2024, Pages 120-130 PDF (1.12 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/zumj.2022.172940.2678 | ||
| Authors | ||
| OLA Elfarargy1; Reham Salem2; Ahmed A. Obaya3; Mostafa Kamel4; Maged Mohammed Ali5; Nora Atef6; DALIA HAMOUDA ELSAYED* 7 | ||
| 1Department of Medical Oncology, Faculty of Medicine, Zagazig University, Egypt | ||
| 2Department of Clinical Oncology and Nuclear Medicine, Faculty of Medicine, Zagazig University, Egypt | ||
| 3clinical oncology and nuclear medicine department, faculty of medicine,zagazig university | ||
| 4Zagazig university | ||
| 5urology department zagazig university | ||
| 6Department of cancer epidemiology and biostatistics National Cancer Institute, Cairo University, Egypt, | ||
| 7MEDICAL ONCOLOGY FACULTY OF MEDICINE ZAGAZIG UNIVERSITY | ||
| Abstract | ||
| Abstract Introduction: Muscle-invasive bladder cancer is common in Egypt. Trimodality chemoradiation post transurethral resection of bladder tumor proved high benefits. Our aim is to show our institute’s experience in using gemcitabine concurrent with radiotherapy post-TURB in an old frail group of patients diagnosed with MIBC regarding efficacy and tolerability. Materials and Methods: This prospective study included 47 patients diagnosed with de novo MIBC in the period between October 2016 and October 2020. Eligible patients underwent maximal TURBT followed by radiation therapy with 65 GY in two phases concomitant weekly gemcitabine (100 mg/m2). Results: The median age was 65.9 years. Males were more common (80.9%) than females. The Median follow-up was 24 months. A complete response was achieved in 34 patients (72.3%). Salvage cystectomy was done for 3 patients who did not achieve CR. chemotherapy was given to another 5 patients of those who did not achieve CR (gemcitabine plus cisplatin /carboplatin). While 5 patients refused any further treatment, only for follow-up regimens. Survival: Median PFS and OS were 40 months and 42 months, respectively. Three-year progression-free survival (PFS) and overall survival (OS) were 66.6% and 75.4%, respectively. Conclusion: Chemoradiation with low dose Gemcitabine is well tolerated and effective post-TURT. It provides an alternative organ-preserving strategy in invasive TCC for old fragile patients. | ||
| Keywords | ||
| bladder cancer; cystectomy; bladder preservation; Gemcitabine | ||
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