Ahmed, E., Abdulhafeez, N., ABDELAZIZ, A., ABDELBAKY, S., EL-FALLAH, A. (2023). Association Between XRCC3 Thr241Met Gene Polymorphism and Susceptibility to Urothelial Carcinoma of the Bladder. test, 40(1), 97-109. doi: 10.21608/bmfj.2022.177773.1721
Enas S. Ahmed; Neveen A. Abdulhafeez; AYA ABDELAZIZ; SHABIEB A ABDELBAKY; ASMAA A. EL-FALLAH. "Association Between XRCC3 Thr241Met Gene Polymorphism and Susceptibility to Urothelial Carcinoma of the Bladder". test, 40, 1, 2023, 97-109. doi: 10.21608/bmfj.2022.177773.1721
Ahmed, E., Abdulhafeez, N., ABDELAZIZ, A., ABDELBAKY, S., EL-FALLAH, A. (2023). 'Association Between XRCC3 Thr241Met Gene Polymorphism and Susceptibility to Urothelial Carcinoma of the Bladder', test, 40(1), pp. 97-109. doi: 10.21608/bmfj.2022.177773.1721
Ahmed, E., Abdulhafeez, N., ABDELAZIZ, A., ABDELBAKY, S., EL-FALLAH, A. Association Between XRCC3 Thr241Met Gene Polymorphism and Susceptibility to Urothelial Carcinoma of the Bladder. test, 2023; 40(1): 97-109. doi: 10.21608/bmfj.2022.177773.1721

Association Between XRCC3 Thr241Met Gene Polymorphism and Susceptibility to Urothelial Carcinoma of the Bladder

Benha Medical Journal
Article 9, Volume 40, Issue 1, May and June 2023, Pages 97-109    PDF (804.15 K)
Document Type: Original Article
DOI: 10.21608/bmfj.2022.177773.1721
Authors
Enas S. Ahmed1; Neveen A. Abdulhafeez2; AYA ABDELAZIZ* 3; SHABIEB A ABDELBAKY4; ASMAA A. EL-FALLAH5
1Department of Clinical and Chemical Pathology Department, Faculty of Medicine, Benha University, Egypt
2Clinical Pathology Department-Faculty Of Medicine-Benha University
3Clinical & Chemical Pathology department, Faculty of Medicine, Benha University, Egypt
4Urology department, Faculty of Medicine, Benha University, Egypt
5assisat professor of Clinical and Chemical Pathology. Faculty of Medicine -Benha University
Abstract
Background: Bladder cancer is a very common malignancy worldwide its exact cause is not known, but it is believed to be multifactorial mostly caused by genetic mutations of tumor suppressor gene, proto-oncogenes and DNA repair genes including XRCC3 Thr241Met gene polymorphism.
Aim of the study: Identify the link between XRCC3 (rs861539) gene polymorphism and the susceptibility to develop urothelial carcinoma of the bladder (UCB) in the Egyptian patients.
Subjects and method: The presence of XRCC3 Thr241Met gene polymorphism (rs 861539) was identified by PCR-RFLP method in 50 patients with urothelial carcinoma of bladder and 50 healthy controls.
Results: XRCC3 Thr 241 Met gene polymorphism CC genotype and C allele demonstrated a substantially increased susceptibility in the UCB group than the control group for the risk to develop UCB (OR 3.69, 95% CL 1.52-8.97) (P =0.003), however, while TT genotype and T allele demonstrated a substantially decreased susceptibility in the UCB group than the control group with a protective effect against UCB development (OR 0.096, 95%CL0.035-0.263) (P
Keywords
XRCC3; Gene polymorphism; Urothelial carcinoma of the bladder; Genotype; Allele
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